A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo - sprookjes - yvandenbroek - TriplyDB

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

http://www.wikidata.org/entity/Q27678738

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Building Bridges: Biocatalytic C–C-Bond Formation toward Multifunctional Products Accessing Nature's diversity through metabolic engineering and synthetic biology Protein design: toward functional metalloenzymes Expanding P450 catalytic reaction space through evolution and engineering Advances in the directed evolution of proteins.Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450.Beyond Iron: Iridium-Containing P450 Enzymes for Selective Cyclopropanations of Structurally Diverse Alkenes.Hole Hopping through Tryptophan in Cytochrome P450 Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transfer P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions.Opportunities for merging chemical and biological synthesis Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination.Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins.Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution.Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin-based catalysts.Catalytic and Biocatalytic Iron Porphyrin Carbene Formation: Effects of Binding Mode, Carbene Substituent, Porphyrin Substituent, and Protein Axial Ligand.Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.Interfacing microbial styrene production with a biocompatible cyclopropanation reaction Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450 Myoglobin-Catalyzed Olefination of Aldehydes Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy.Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds.P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo.Metalloenzyme design and engineering through strategic modifications of native protein scaffolds.Recent advances in engineering proteins for biocatalysis.Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations.Artificial concurrent catalytic processes involving enzymes.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.The nature of chemical innovation: new enzymes by evolution.A redox-mediated Kemp eliminase.Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions.Improving artificial metalloenzymes' activity by optimizing electron transfer.A Retrosynthesis Approach for Biocatalysis in Organic Synthesis.Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions.Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes.

P2860

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P2860

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

http://www.wikidata.org/entity/Q27678738

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@ast

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@en

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@nl

type

label

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@ast

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@en

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@nl

prefLabel

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@ast

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@en

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@nl

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Nature Chemical Biology

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A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

@en

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Arvind Kannan

http://www.w3.org/2001/XMLSchema#string

Eric M Brustad

http://www.w3.org/2001/XMLSchema#string

Maraia E Ener

http://www.w3.org/2001/XMLSchema#string

Pedro S Coelho

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Stefanie A Baril

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Z Jane Wang

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P2860

Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Pivotal role of water in the mechanism of P450BM-3

Coot: model-building tools for molecular graphics

Integration, scaling, space-group assignment and post-refinement

Refinement of macromolecular structures by the maximum-likelihood method

The CCP4 suite: programs for protein crystallography

Scaling and assessment of data quality

Stereoselective cyclopropanation reactions

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

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485-7

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scholarly article

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819821

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10.1038/NCHEMBIO.1278

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8

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9

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2013-08-01T00:00:00Z

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1045027711

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23792734

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3720782

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