A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion
about
Disruption of CEP290 microtubule/membrane-binding domains causes retinal degenerationIntegrin cytoplasmic tail interactionsMechanical dynamics in live cells and fluorescence-based force/tension sensorsSkap2 is required for β2 integrin-mediated neutrophil recruitment and functions.Talins and kindlins: partners in integrin-mediated adhesion.Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis.Membrane-induced structural rearrangement and identification of a novel membrane anchor in talin F2F3Structural and mechanistic insights into the recruitment of talin by RIAM in integrin signalingStructural mechanism of integrin inactivation by filamin.Blocking neutrophil integrin activation prevents ischemia-reperfusion injuryExome Sequencing of a Pedigree Reveals S339L Mutation in the TLN2 Gene as a Cause of Fifth Finger Camptodactyly.Wdr1-Dependent Actin Reorganization in Platelet Activation.Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in miceStructural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory ConfigurationLeukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activationAtomic-level description of protein-lipid interactions using an accelerated membrane model.Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.YMO1 suppresses invasion and metastasis by inhibiting RhoC signaling and predicts favorable prognosis in hepatocellular carcinomaTalin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing.Mechanisms of talin-dependent integrin signaling and crosstalkIntegrin function in vascular biology: a view from 2013.Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation.Identification, modeling, and characterization studies of Tetrahymena thermophila myosin FERM domains suggests a conserved core fold but functional differences.Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.Pull and push: talin activation for integrin signaling.NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia.Talin autoinhibition is required for morphogenesis.The molecular basis of talin2's high affinity toward β1-integrin.The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation.Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form.Gα13 Switch Region 2 Relieves Talin Autoinhibition to Activate αIIbβ3 Integrin.The conformational states of talin autoinhibition complex and its activation under forces.
P2860
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P2860
A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@ast
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@en
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@nl
type
label
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@ast
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@en
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@nl
prefLabel
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@ast
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@en
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@nl
P2093
P2860
P3181
P356
P1433
P1476
A novel membrane-dependent on/ ...... main at sites of cell adhesion
@en
P2093
Edward F Plow
Esen Goksoy
H Dhanuja Perera
Jamila Hirbawi
Pallavi Dwivedi
Rongguang Zhang
Xianqiang Song
P2860
P2888
P304
P3181
P356
10.1038/CR.2012.97
P577
2012-11-01T00:00:00Z
P5875
P6179
1023699074