The crystal structures of TrkA and TrkB suggest key regions for achieving selective inhibition
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Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signalingAssessing the range of kinase autoinhibition mechanisms in the insulin receptor familyStructural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase InhibitorsNTRK gene fusions as novel targets of cancer therapy across multiple tumour typesOral and craniofacial manifestations and two novel missense mutations of the NTRK1 gene identified in the patient with congenital insensitivity to pain with anhidrosisTargeting Neuroblastoma Cell Surface Proteins: Recommendations for Homology Modeling of hNET, ALK, and TrkBImpairment of kindling development in phospholipase Cγ1 heterozygous mice.Mechanisms of activation of receptor tyrosine kinases: monomers or dimers.Neurotrophin signaling via TrkB and TrkC receptors promotes the growth of brain tumor-initiating cells.Identification of Existing Drugs That Effectively Target NTRK1 and ROS1 Rearrangements in Lung Cancer.GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.Proliferation enhanced by NGF-NTRK1 signaling makes pancreatic cancer cells more sensitive to 2DG-induced apoptosis.Structural characterization of nonactive site, TrkA-selective kinase inhibitors.Tropomyosin receptor kinase inhibitors: a patent update 2009 - 2013.Evaluation of WO2015042088 A1 - a novel urea-based scaffold for TrkA inhibition.Structure-functional prediction and analysis of cancer mutation effects in protein kinases.Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and γ-secretases.Phenotypic heterogeneity of intellectual disability in patients with congenital insensitivity to pain with anhidrosis: A case report and literature review.Inhibiting TRK Proteins in Clinical Cancer Therapy.TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.
P2860
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P2860
The crystal structures of TrkA and TrkB suggest key regions for achieving selective inhibition
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The crystal structures of TrkA ...... achieving selective inhibition
@ast
The crystal structures of TrkA ...... achieving selective inhibition
@en
The crystal structures of TrkA ...... achieving selective inhibition
@nl
type
label
The crystal structures of TrkA ...... achieving selective inhibition
@ast
The crystal structures of TrkA ...... achieving selective inhibition
@en
The crystal structures of TrkA ...... achieving selective inhibition
@nl
prefLabel
The crystal structures of TrkA ...... achieving selective inhibition
@ast
The crystal structures of TrkA ...... achieving selective inhibition
@en
The crystal structures of TrkA ...... achieving selective inhibition
@nl
P2093
P1476
The crystal structures of TrkA ...... achieving selective inhibition
@en
P2093
J Y Crenne
T Bertrand
P304
P356
10.1016/J.JMB.2012.08.002
P407
P577
2012-10-26T00:00:00Z