Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications - sprookjes - yvandenbroek - TriplyDB

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

http://www.wikidata.org/entity/Q27696225

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Cyanobacterial Metabolite Calothrixins: Recent Advances in Synthesis and Biological Evaluation Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics Synthesis and Cytotoxicity Evaluation of C4- and C5-Modified Analogues of the α,β-Unsaturated Lactone of Pironetin Structures of potent anticancer compounds bound to tubulin Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents.In vivo biotransformations of antibody-drug conjugates.Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates.A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions.Strategies and challenges for the next generation of antibody-drug conjugates.Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates.New insight on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling.A phase 1, dose-escalation study of PF-06664178, an anti-Trop-2/Aur0101 antibody-drug conjugate in patients with advanced or metastatic solid tumors.A practical approach to asymmetric synthesis of dolastatin 10.Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.Calculated conjugated payload from immunoassay and LC-MS intact protein analysis measurements of antibody-drug conjugate.Unconjugated payload quantification and DAR characterization of antibody-drug conjugates using high-resolution MS.Integrating cross-linking experiments with ab initio protein-protein docking.Expanding the Reach of Antibody-Drug Conjugates.Thiazoles in Peptides and Peptidomimetics RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models

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P2860

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

http://www.wikidata.org/entity/Q27696225

description

2014 nî lūn-bûn

@nan

2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@ast

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@en

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@nl

type

label

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@ast

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@en

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@nl

prefLabel

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@ast

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@en

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@nl

P1433

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P1433

Journal of Medicinal Chemistry

P1476

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications

@en

P2093

Alexander Porte

http://www.w3.org/2001/XMLSchema#string

Alison H Varghese

http://www.w3.org/2001/XMLSchema#string

Andreas Maderna

http://www.w3.org/2001/XMLSchema#string

Beth C Vetelino

http://www.w3.org/2001/XMLSchema#string

Carolyn A Leverett

http://www.w3.org/2001/XMLSchema#string

Chakrapani Subramanyam

http://www.w3.org/2001/XMLSchema#string

Christopher J O'Donnell

http://www.w3.org/2001/XMLSchema#string

Cynthia Song

http://www.w3.org/2001/XMLSchema#string

Frank Loganzo

http://www.w3.org/2001/XMLSchema#string

Hud Risley

http://www.w3.org/2001/XMLSchema#string

P304

10527-10543

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scholarly article

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2011986

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10.1021/JM501649K

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24

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57

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Jayvardhan Pandit

Kathleen A Farley

Matthew Doroski

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2014-12-26T00:00:00Z

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25431858

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