Substrate specificity and affinity of a protein modulated by bound water molecules
about
Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulationQuantifying the molecular origins of opposite solvent effects on protein-protein interactionsFunctional equality in the absence of structural similarity: an added dimension to molecular mimicryCrystal structures of the BtuF periplasmic-binding protein for vitamin B12 suggest a functionally important reduction in protein mobility upon ligand bindingThe Molecular Basis of Inhibition of Golgi α-Mannosidase II by Mannostatin AComputational design of ligand binding is not a solved problemAffinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineeringReplacement of water molecules in a phosphate binding site by furanoside-appended lin-benzoguanine ligands of tRNA-guanine transglycosylase (TGT)Structure of cytochrome P450eryF involved in erythromycin biosynthesisBound water molecules and conformational stabilization help mediate an antigen-antibody associationThe role of water in sequence-independent ligand binding by an oligopeptide transporter proteinThe X-ray structure of the PurR-guanine-purF operator complex reveals the contributions of complementary electrostatic surfaces and a water-mediated hydrogen bond to corepressor specificity and binding affinityCrystal structure and mutational analysis of the Escherichia coli putrescine receptor. Structural basis for substrate specificityExperimental resolution of the free energies of aqueous solvation contributions to ligand-protein binding: quinone-QA site interactions in the photosynthetic reaction center proteinDesiccation tolerance of prokaryotesA hot spot of binding energy in a hormone-receptor interfaceMicroscopic insight into thermodynamics of conformational changes of SAP-SLAM complex in signal transduction cascade.Interaction between bound water molecules and local protein structures: A statistical analysis of the hydrogen bond structures around bound water molecules.The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to bindingMutations that affect ligand binding to the Escherichia coli aspartate receptor: implications for transmembrane signaling.Some characteristics of a serine proteinase isolated from an extreme thermophile for use in kinetically controlled peptide bond synthesis.Analysis of the binding surfaces of proteins.Evaluation and improvement of multiple sequence methods for protein secondary structure prediction.Two-step mechanism that determines the donor binding specificity of human UDP-N-acetylhexosaminyltransferase.Water molecules participate in proteinase-inhibitor interactions: crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with Streptomyces griseus proteinase B.Waterdock 2.0: Water placement prediction for Holo-structures with a pymol pluginPatterns of protein protein interactions in salt solutions and implications for protein crystallization.Water at biomolecular binding interfaces.Thermodynamics of water mediating protein-ligand interactions in cytochrome P450cam: a molecular dynamics study.Ordered water molecules as key allosteric mediators in a cooperative dimeric hemoglobinHow reverse turns may mediate the formation of helical segments in proteins: an x-ray model.Thermodynamic analysis of the binding of component enzymes in the assembly of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus.The solvation structure of alprazolam.Computational analysis of BACE1-ligand complex crystal structures and linear discriminant analysis for identification of BACE1 inhibitors with anti P-glycoprotein binding property.Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: variation of common themes.Binding energy and catalysis. Fluorinated and deoxygenated glycosides as mechanistic probes of Escherichia coli (lacZ) beta-galactosidase.Importance of accurate charges in molecular docking: quantum mechanical/molecular mechanical (QM/MM) approachGlobal changes in local protein dynamics reduce the entropic cost of carbohydrate binding in the arabinose-binding protein.Combining solvent thermodynamic profiles with functionality maps of the Hsp90 binding site to predict the displacement of water molecules.High-affinity inhibitors of tRNA-guanine transglycosylase replacing the function of a structural water cluster.
P2860
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P2860
Substrate specificity and affinity of a protein modulated by bound water molecules
description
1989 nî lūn-bûn
@nan
1989 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Substrate specificity and affinity of a protein modulated by bound water molecules
@ast
Substrate specificity and affinity of a protein modulated by bound water molecules
@en
Substrate specificity and affinity of a protein modulated by bound water molecules
@nl
type
label
Substrate specificity and affinity of a protein modulated by bound water molecules
@ast
Substrate specificity and affinity of a protein modulated by bound water molecules
@en
Substrate specificity and affinity of a protein modulated by bound water molecules
@nl
prefLabel
Substrate specificity and affinity of a protein modulated by bound water molecules
@ast
Substrate specificity and affinity of a protein modulated by bound water molecules
@en
Substrate specificity and affinity of a protein modulated by bound water molecules
@nl
P2093
P356
P1433
P1476
Substrate specificity and affinity of a protein modulated by bound water molecules
@en
P2093
P2888
P356
10.1038/340404A0
P407
P577
1989-08-03T00:00:00Z
P6179
1014349063