Refined solution structure of the oligomerization domain of the tumour suppressor p53
about
Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm traffickingAn induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificityRegulation of p53 tetramerization and nuclear export by ARCA unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteinsProtein complexes studied by NMR spectroscopyImpact of low-frequency hotspot mutation R282Q on the structure of p53 DNA-binding domain as revealed by crystallography at 1.54 Å resolutionStructural evolution of p53, p63, and p73: Implication for heterotetramer formationInteraction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerStructure and Kinetic Stability of the p63 Tetramerization DomainPhysical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53Three-dimensional reconstruction of protein networks provides insight into human genetic diseaseTracing the evolution of the p53 tetramerization domainStructure of full-length p53 tumor suppressor probed by chemical cross-linking and mass spectrometry.Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein.Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription.Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.Oligomerization enhances the binding affinity of a silver biomineralization peptide and catalyzes nanostructure formation.Topology Engineering of Proteins in Vivo Using Genetically Encoded, Mechanically Interlocking SpyX Modules for Enhanced Stabilityp53 regulation by post-translational modification and nuclear retention in response to diverse stresses.A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesAn inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma.Comparison of the protein-protein interfaces in the p53-DNA crystal structures: towards elucidation of the biological interface.Strategies for manipulating the p53 pathway in the treatment of human cancer.Hydrophobic side-chain size is a determinant of the three-dimensional structure of the p53 oligomerization domain.The role of tetramerization in p53 function.Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivationNew methods of structure refinement for macromolecular structure determination by NMR.Core domain interactions in full-length p53 in solutionRecognition of RNA by the p53 tumor suppressor protein in the yeast three-hybrid system.Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3aDetermination of the structures of symmetric protein oligomers from NMR chemical shifts and residual dipolar couplings.Structural basis for understanding oncogenic p53 mutations and designing rescue drugs.Utilizing NMR to study the structure of growth-inhibitory proteins.Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis.p53 mutations and expression in breast carcinoma in situ.Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations.Quaternary structure of p53: the light at the end of the tunnel.p53 RNA interactions: new clues in an old mystery.
P2860
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P2860
Refined solution structure of the oligomerization domain of the tumour suppressor p53
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@ast
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@en
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@nl
type
label
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@ast
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@en
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@nl
prefLabel
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@ast
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@en
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@nl
P2093
P2860
P356
P1476
Refined solution structure of the oligomerization domain of the tumour suppressor p53
@en
P2093
J G Omichinski
K Sakaguchi
W M Kennedy
P2860
P304
P356
10.1038/NSB0495-321
P577
1995-04-01T00:00:00Z