Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences
about
MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)Interatomic potentials and solvation parameters from protein engineering data for buried residuesQuantification of helix-helix binding affinities in micelles and lipid bilayersExploring steric constraints on protein mutations using MAGE/PROBEMolecular analysis of a series of alleles in humans with reduced activity at the triosephosphate isomerase locusPredicting absolute ligand binding free energies to a simple model siteDetecting O2 binding sites in protein cavitiesStructural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active siteExperimental verification of the 'stability profile of mutant protein' (SPMP) data using mutant human lysozymesContribution of amino acid substitutions at two different interior positions to the conformational stability of human lysozymeSolid-state synthesis and mechanical unfolding of polymers of T4 lysozymeUse of a non-rigid region in T4 lysozyme to design an adaptable metal-binding siteStructural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozymeA cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helixA test of proposed rules for helix capping: Implications for protein designAccommodation of a highly symmetric core within a symmetric protein superfoldStructural Rigidity of a Large Cavity-containing Protein Revealed by High-pressure CrystallographyUse of experimental crystallographic phases to examine the hydration of polar and nonpolar cavities in T4 lysozymeEvaluation at atomic resolution of the role of strain in destabilizing the temperature-sensitive T4 lysozyme mutant Arg 96 → HisContributions of all 20 amino acids at site 96 to the stability and structure of T4 lysozymeBoron Mimetics: 1,2-Dihydro-1,2-azaborines Bind inside a Nonpolar Cavity of T4 LysozymeSite-directed spin labeling of a genetically encoded unnatural amino acidHydrogen Bonding of 1,2-Azaborines in the Binding Cavity of T4 Lysozyme Mutants: Structures and ThermodynamicsA relationship between protein stability and protein functionA ligand-gated, hinged loop rearrangement opens a channel to a buried artificial protein cavityAre the parameters of various stabilization factors estimated from mutant human lysozymes compatible with other proteins?Theoretical studies of the response of a protein structure to cavity-creating mutations.Site-specific incorporation of biophysical probes into proteins.De novo design of the hydrophobic core of ubiquitin.Role of cavities and hydration in the pressure unfolding of T4 lysozyme.A test of the "jigsaw puzzle" model for protein folding by multiple methionine substitutions within the core of T4 lysozyme.Free-solution label-free detection of alpha-crystallin chaperone interactions by back-scattering interferometry.CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation.Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation.Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoproteinAlteration of T4 lysozyme structure by second-site reversion of deleterious mutations.Mutational analysis of the BPTI folding pathway: I. Effects of aromatic-->leucine substitutions on the distribution of folding intermediatesUncharged S4 residues and cooperativity in voltage-dependent potassium channel activationDeterminants of voltage-dependent gating and open-state stability in the S5 segment of Shaker potassium channelsGuanidinium derivatives bind preferentially and trigger long-distance conformational changes in an engineered T4 lysozyme.
P2860
Q24324139-A3A175DC-0DBC-49FC-87DE-B658EDA189EDQ24644861-EE350F0D-909E-491D-8C39-F8A1C93FB99EQ24645279-C7F98CE5-2140-4A75-BAB7-FA2CD3F74459Q24672377-1449B323-2527-4E9A-B029-AB26DDE70D82Q24676492-713C998A-C1BE-43F1-8E0C-984F70BF1DA8Q24683618-6A8FE6C2-091D-4B57-8898-E94EC9201DD0Q27350379-35870B39-061C-478F-88C8-2D01F4394D0AQ27619269-F2DADC64-B3E7-4E73-94A1-28A690990DC8Q27619558-B5C2B5FA-70C5-414F-B615-33D9732F12AEQ27620339-F33AC1ED-7B91-46AA-A0B7-C7A0A6CC4273Q27620841-11D701A9-0EDA-447F-8223-8508729EE15DQ27622679-B4EAD8B7-5CA3-47F8-9488-A59DF60DAF83Q27631323-8BBAC4E8-617A-4190-807C-E3F35FEDF55BQ27636798-60FF8A1F-EA64-462C-8F21-CE25A2896469Q27637826-AE318FFA-3959-476F-8436-3556DF97786CQ27642593-50B1B6A5-346F-4A43-9D82-0E6FF6181D49Q27643796-A846953D-4C8B-4344-B702-35195B52531EQ27652053-61FC9847-15BC-4C7F-86CF-5B0799B96650Q27655042-F609218C-8A65-4BF5-8F05-4A170921E7DDQ27655047-EAA8ED24-876A-4272-B2CD-D808DABBAF05Q27657048-025A1D2F-BBDD-4943-A03A-1BADEB1C5942Q27658545-05A8652B-144B-41C7-BAC7-8C541FCBBB61Q27728018-09FEBD95-841C-473A-9A63-AD48DFAE9A65Q27730341-5B2BDFBB-D8EE-40B3-A59A-79F6699E6DE5Q27732870-EC59EC35-6558-4149-B0C4-2DD2FADC2EE5Q28211874-DDB3CD2A-83FF-4F0C-A4E9-C1767B4FC4E4Q30326429-F013690C-F6BD-44C4-92D7-453C5BAD1826Q30421079-19ED3566-5994-4035-9396-65F16E6AA7B4Q30427609-42D9AEE7-C1F1-4C9B-9B36-820B98642D82Q30848822-029E1061-2623-4631-966D-EC4EDA40CB0DQ33367870-82AFB959-EE2B-48DB-B582-87F6277DB636Q33403849-22FD1D0B-BDBB-4A2E-ADC5-2293AF004B5CQ33929489-76008403-F8AA-4F8C-A081-E9B44FD64518Q34133399-2D5231B1-98BC-4E73-BBEA-8EB054C30AB9Q34347265-D4A466B8-5014-4F60-A6BA-589E38C5CBDEQ36280203-7FBB84C7-D5F6-4D33-B68B-0F48A28AF784Q36280455-ECA52831-A7B9-4ED2-BD90-AA6D33A5AF71Q36411946-57133A1B-C621-4D9B-A8A2-A7E85DF8B37BQ36438983-8C971DDE-97E6-46A4-AB79-C58C266A72BBQ36458316-A7167AD5-08BC-44DC-9F79-A5990DE62C3A
P2860
Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences
description
1993 nî lūn-bûn
@nan
1993 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Similar hydrophobic replacemen ...... and thermodynamic consequences
@ast
Similar hydrophobic replacemen ...... and thermodynamic consequences
@en
Similar hydrophobic replacemen ...... and thermodynamic consequences
@nl
type
label
Similar hydrophobic replacemen ...... and thermodynamic consequences
@ast
Similar hydrophobic replacemen ...... and thermodynamic consequences
@en
Similar hydrophobic replacemen ...... and thermodynamic consequences
@nl
prefLabel
Similar hydrophobic replacemen ...... and thermodynamic consequences
@ast
Similar hydrophobic replacemen ...... and thermodynamic consequences
@en
Similar hydrophobic replacemen ...... and thermodynamic consequences
@nl
P2093
P356
P1476
Similar hydrophobic replacemen ...... and thermodynamic consequences
@en
P2093
A E Eriksson
B W Matthews
P304
P356
10.1006/JMBI.1993.1077
P407
P577
1993-02-05T00:00:00Z