Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin
about
A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helixThe A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related creviceDesign of an Active Ultrastable Single-chain Insulin Analog: SYNTHESIS, STRUCTURE, AND THERAPEUTIC IMPLICATIONSCrystal structure of ultralente--a microcrystalline insulin suspensionNon-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer InterfaceFully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein CrystallographyStructural Integrity of the B24 Site in Human Insulin Is Important for Hormone FunctionalityRecombinant A22(G)-B31 (R)-human insulin. A22 addition introduces conformational mobility in B chain C-terminusThe structures of T6, T3R3 and R6 bovine insulin: combining X-ray diffraction and absorption spectroscopyInsight into the Structural and Biological Relevance of the T/R Transition of the N-Terminus of the B-Chain in Human InsulinBiosynthetic engineered B28(K)-B29(P) human insulin monomer structure in water and in water/acetonitrile solutionsContribution of TyrB26 to the Function and Stability of Insulin: STRUCTURE-ACTIVITY RELATIONSHIPS AT A CONSERVED HORMONE-RECEPTOR INTERFACE.Intrinsic fibrillation of fast-acting insulin analogs.Conformational dynamics of insulin.Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chainA novel complex of a phenolic derivative with insulin: structural features related to the T-->R transition.Atomic force microscopy of crystalline insulins: the influence of sequence variation on crystallization and interfacial structure.Structural studies of a crystalline insulin analog complex with protamine by atomic force microscopy.Amyloid fibrillation of insulin under water-limited conditionsThree-dimensional structural interactions of insulin and its receptor.Isolation and Characterization of Acetylated Derivative of Recombinant Insulin Lispro Produced in Escherichia coliEnhanced insulin absorption from sublingual microemulsions: effect of permeation enhancers.The structure and function of insulin: decoding the TR transitionInsulin analogs for the treatment of diabetes mellitus: therapeutic applications of protein engineering.Insulin fibrillation and protein design: topological resistance of single-chain analogs to thermal degradation with application to a pump reservoir.Physicochemical basis for the rapid time-action of LysB28ProB29-insulin: dissociation of a protein-ligand complexThe structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.Insulin lispro: its role in the treatment of diabetes mellitus.In Quest for Improved Drugs against Diabetes: The Added Value of X-ray Powder Diffraction Methods.Equilibrium Ensembles for Insulin Folding from Bias-Exchange Metadynamics.Insulin-From its Discovery to the Industrial Synthesis of Modern Insulin Analogues.The effects of electromagnetic pulses (EMP) on the bioactivity of insulin and a preliminary study of mechanism.Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations.Computational study of the activity, dynamics, energetics and conformations of insulin analogues using molecular dynamics simulations: Application to hyperinsulinemia and the critical residue B26.Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin.Design and folding of [GluA4(ObetaThrB30)]insulin ("ester insulin"): a minimal proinsulin surrogate that can be chemically converted into human insulinRapid-Acting and Human Insulins: Hexamer Dissociation Kinetics upon Dilution of the Pharmaceutical FormulationInhibition of Insulin Amyloid Fibrillation by a Novel Amphipathic Heptapeptide: MECHANISTIC DETAILS STUDIED BY SPECTROSCOPY IN COMBINATION WITH MICROSCOPYUltra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K.Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis.
P2860
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P2860
Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin
description
1995 nî lūn-bûn
@nan
1995 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@ast
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@en
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@nl
type
label
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@ast
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@en
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@nl
prefLabel
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@ast
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@en
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@nl
P2093
P1433
P1476
Role of C-terminal B-chain res ...... ric LysB28ProB29-human insulin
@en
P2093
P304
P356
10.1016/S0969-2126(01)00195-2
P577
1995-06-15T00:00:00Z