Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
about
Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrateSynapsin I is structurally similar to ATP-utilizing enzymes.Studies of the CobA-type ATP:Co(I)rrinoid adenosyltransferase enzyme of Methanosarcina mazei strain Go1Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulationsInsights into Hsp70 Chaperone Activity from a Crystal Structure of the Yeast Hsp110 Sse1Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining ConformationCrystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATPExploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functionsMovement protein Pns6 of rice dwarf phytoreovirus has both ATPase and RNA binding activitiesA fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Identification of calcium-binding proteins associated with the human sperm plasma membraneDissection of the ATP-binding domain of the chaperone hsc70 for interaction with the cofactor Hap46.Stress genes and proteins in the archaea.Mortalin/GRP75 binds to complement C9 and plays a role in resistance to complement-dependent cytotoxicity.Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.Divergent functional properties of the ribosome-associated molecular chaperone Ssb compared with other Hsp70s.ATPase-defective derivatives of Escherichia coli DnaK that behave differently with respect to ATP-induced conformational change and peptide releaseT antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesisOn the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60.Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis.Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.A functional DnaK dimer is essential for the efficient interaction with Hsp40 heat shock proteinA Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human MacrophagesRole of Na+ and K+ in enzyme function.Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70.Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.Molecular Mechanisms of Enzyme Activation by Monovalent Cations.HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum.Interference between proteins Hap46 and Hop/p60, which bind to different domains of the molecular chaperone hsp70/hsc70.In Silico Molecular Modeling and Docking Studies on Novel Mutants (E229V, H225P and D230C) of the Nucleotide-Binding Domain of Homo sapiens Hsp70.Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein.Structural basis of interdomain communication in the Hsc70 chaperone.Sulfatide-Hsp70 interaction promotes Hsp70 clustering and stabilizes binding to unfolded protein.Unique peptide substrate binding properties of 110-kDa heat-shock protein (Hsp110) determine its distinct chaperone activityHistidine 89 is an essential residue for Hsp70 in the phosphate transfer reaction.A disulfide-bonded DnaK dimer is maintained in an ATP-bound stateThe second metal-binding site of 70 kDa heat-shock protein is essential for ADP binding, ATP hydrolysis and ATP synthesis
P2860
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P2860
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@ast
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@en
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@nl
type
label
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@ast
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@en
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@nl
prefLabel
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@ast
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@en
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@nl
P2093
P3181
P1433
P1476
Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain
@en
P2093
P304
P3181
P356
10.1016/S0969-2126(97)00197-4
P407
P577
1997-03-15T00:00:00Z