Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.
about
Accumulating evidence supports a taste component for free fatty acids in humansEndoplasmic reticulum stress and type 2 diabetesThe action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitusDC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db miceStress-induced dissociations between intracellular calcium signaling and insulin secretion in pancreatic isletsNovel translocation responses of cytosolic phospholipase A2alpha fluorescent proteins.Lipid receptors and islet function: therapeutic implications?PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cellsNifedipine protects INS-1 β-cell from high glucose-induced ER stress and apoptosisPancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational AnalysisNovel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle.Gustducin couples fatty acid receptors to GLP-1 release in colon.Fatty acid receptors as new therapeutic targets for diabetes.Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in miceThe fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.GPR40: good cop, bad cop?Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes.β-Arrestins: multifunctional signaling adaptors in type 2 diabetes.GPR40 agonists for the treatment of type 2 diabetes: life after 'TAKing' a hit.20-HETE attenuates the response of glucose-stimulated insulin secretion through the AKT/GSK-3β/Glut2 pathway.The Role and Future of FFA1 as a Therapeutic Target.Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development.Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis.The Pancreatic β-Cell: A Bioenergetic Perspective.Polymorphic Variation in FFA Receptors: Functions and Consequences.Free Fatty Acid Receptor 1 (FFAR1) as an Emerging Therapeutic Target for Type 2 Diabetes Mellitus: Recent Progress and Prevailing Challenges.Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis.Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells.Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine.Fatty acids increase hepatitis B virus X protein stabilization and HBx-induced inflammatory gene expression.Lack of GPR40/FFAR1 does not induce diabetes even under insulin resistance condition.Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells.Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion.Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes.Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators.
P2860
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P2860
Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40.
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Free fatty acids increase cyto ...... s through activation of GPR40.
@ast
Free fatty acids increase cyto ...... s through activation of GPR40.
@en
Free fatty acids increase cyto ...... s through activation of GPR40.
@nl
type
label
Free fatty acids increase cyto ...... s through activation of GPR40.
@ast
Free fatty acids increase cyto ...... s through activation of GPR40.
@en
Free fatty acids increase cyto ...... s through activation of GPR40.
@nl
altLabel
Free fatty acids increase cyto ...... ls through activation of GPR40
@en
prefLabel
Free fatty acids increase cyto ...... s through activation of GPR40.
@ast
Free fatty acids increase cyto ...... s through activation of GPR40.
@en
Free fatty acids increase cyto ...... s through activation of GPR40.
@nl
P3181
P1476
Free fatty acids increase cyto ...... s through activation of GPR40.
@en
P2093
Michael Schaefer
Susanne Schnell
P304
P3181
P356
10.1016/J.MCE.2006.09.013
P407
P577
2007-01-15T00:00:00Z