The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast.
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Achieving Metabolic Flux Analysis for S. cerevisiae at a Genome-Scale: Challenges, Requirements, and ConsiderationsAging and cell death in the other yeasts, Schizosaccharomyces pombe and Candida albicansYCL047C/POF1 is a novel nicotinamide mononucleotide adenylyltransferase (NMNAT) in Saccharomyces cerevisiae.Ccm1p/Ygr150cp, a pentatricopeptide repeat protein, is essential to remove the fourth intron of both COB and COX1 pre-mRNAs in Saccharomyces cerevisiae.Phosphate-responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae.Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells.SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycleYeast sirtuins and the regulation of aging.Recent progress in metabolic signaling pathways regulating aging and life spanExpression and identification of a thermostable malate dehydrogenase from multicellular prokaryote Streptomyces avermitilis MA-4680.The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction.Respected Sir(2): magic target for diabetesA two-way street: reciprocal regulation of metabolism and signalling.Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity.Cytosolic malate dehydrogenase regulates senescence in human fibroblasts.Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry.Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiaeIdentification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels.Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function.Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae.Mice expressing reduced levels of hepatic glucose-6-phosphatase-α activity do not develop age-related insulin resistance or obesity.Dietary restriction, mitochondrial function and aging: from yeast to humans.NAD(+)/NADH and skeletal muscle mitochondrial adaptations to exercise.Mitochondria and organismal longevity.The coordination of nuclear and mitochondrial communication during aging and calorie restrictionThe Mitochondrial Basis of Aging.The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics.Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD(+) homeostasis and contributes to longevity.Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response.Mitochondrial energy metabolism and redox signaling in brain aging and neurodegenerationCaloric restriction, SIRT1 and longevityIn vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans.NAD(+) Metabolism in Age-Related Hearing LossKluyveromyces lactis: a suitable yeast model to study cellular defense mechanisms against hypoxia-induced oxidative stress.Nature's inordinate fondness for metabolic enzymes: why metabolic enzyme loci are so frequently targets of selection.Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation.
P2860
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P2860
The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The malate-aspartate NADH shut ...... life span extension in yeast.
@ast
The malate-aspartate NADH shut ...... life span extension in yeast.
@en
The malate-aspartate NADH shut ...... life span extension in yeast.
@nl
type
label
The malate-aspartate NADH shut ...... life span extension in yeast.
@ast
The malate-aspartate NADH shut ...... life span extension in yeast.
@en
The malate-aspartate NADH shut ...... life span extension in yeast.
@nl
prefLabel
The malate-aspartate NADH shut ...... life span extension in yeast.
@ast
The malate-aspartate NADH shut ...... life span extension in yeast.
@en
The malate-aspartate NADH shut ...... life span extension in yeast.
@nl
P2093
P2860
P356
P1433
P1476
The malate-aspartate NADH shut ...... life span extension in yeast.
@en
P2093
Craig Skinner
Erin Easlon
Felicia Tsang
P2860
P304
P356
10.1101/GAD.1648308
P407
P577
2008-04-01T00:00:00Z