Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.
about
A wolf in sheep's clothing: SV40 co-opts host genome maintenance proteins to replicate viral DNADistinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forksIsolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicaseA requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replicationMolecular architecture of the human GINS complex.DNA binding and helicase actions of mouse MCM4/6/7 helicase.Interactions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties.The Eukaryotic Replisome Goes Under the MicroscopeThe Mcm2-7 replicative helicase: a promising chemotherapeutic targetRoles of DNA helicases in the maintenance of genome integrityDynamic coupling between the motors of DNA replication: hexameric helicase, DNA polymerase, and primaseCrystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicaseA conserved MCM single-stranded DNA binding element is essential for replication initiationMolecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress.Differences in the single-stranded DNA binding activities of MCM2-7 and MCM467: MCM2 and MCM5 define a slow ATP-dependent step.Nascent transcription of MCM2-7 is important for nuclear localization of the minichromosome maintenance complex in G1Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex.Helicase loading at chromosomal origins of replicationThe effect of DNA-dependent protein kinase on adeno-associated virus replicationThe Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly.DNA unwinding assay using streptavidin-bound oligonucleotides.The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 functionOrigin-dependent inverted-repeat amplification: a replication-based model for generating palindromic amplicons.Distributed biotin-streptavidin transcription roadblocks for mapping cotranscriptional RNA folding.An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7The DNA-unwinding mechanism of the ring helicase of bacteriophage T7.Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damageCharacterization of Leishmania donovani MCM4: expression patterns and interaction with PCNA.Molecular architecture of a multifunctional MCM complexThe ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.Juvenile hormone-receptor complex acts on mcm4 and mcm7 to promote polyploidy and vitellogenesis in the migratory locust.Mechanisms of helicases.The mini-chromosome maintenance (Mcm) complexes interact with DNA polymerase α-primase and stimulate its ability to synthesize RNA primersDNA unwinding by ring-shaped T4 helicase gp41 is hindered by tension on the occluded strandThe PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding.Analyses of the interaction between the origin binding domain from simian virus 40 T antigen and single-stranded DNA provide insights into DNA unwinding and initiation of DNA replicationDpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase.
P2860
Q21090484-D79B8253-9324-4B79-BD40-0CD23117E453Q24543916-4B907F0A-6CE0-4C60-B442-6B00AFA8286BQ24548452-F6E50D8A-0DBA-4A43-AF2E-CCAF18E12393Q24561565-7271C31F-46E8-4D19-AA61-38E9A3470BE8Q24681607-B54F5E19-C910-45C5-A1C1-5D8E283341DDQ24794720-DED51B96-5913-4395-ABB5-6249283F9D91Q24812763-0A97533F-1E12-418A-92C2-1912858914D2Q26752772-27ED90DF-A72A-4AD0-88BE-6E7F242C6351Q26861045-67E418F5-CC05-44B1-BB49-F88F867D9EE6Q26861945-91F464BC-C808-49B2-88FA-532443C9865EQ26998987-7DBE9996-E920-4C80-BBDE-BA0C61873E0DQ27653118-99616EE4-C5EA-462A-B8ED-2D5037D41466Q27682741-128375E2-A9FE-41A8-ADFE-84D3C4C1B4C8Q27931822-FD1A27BB-EF01-4FD2-BF6D-E231D275C65FQ27933812-96FEEB2B-9DD4-4084-9D4B-A3E719361C60Q27936414-913FA09A-9C54-4279-A95E-E8C9821525BDQ27936752-02EB4897-A76D-4AD9-8BEA-8608B2F12C65Q28281309-9CEF846E-C719-4AAA-A9E9-1398058A9CECQ28289537-04597392-85B7-428C-A4D5-FD901348B324Q28744087-A32577E3-AADA-4D12-A034-698146A88A70Q29976890-5502906F-20F6-4FA8-881F-B64C79844431Q33264860-D7F6BC33-C112-4D3D-9E85-917904F39EF0Q33699332-1F0C410E-0B58-4198-87CA-40EFCFDD0D19Q33855637-D67AA8DF-D5E5-4E95-B585-E531A6B836FEQ33878041-E1656714-BBB4-4B66-ADF1-865FA9C370F1Q33878186-79158E78-286E-4792-BF78-F3985506C839Q33904389-CF76D04B-677E-4C1F-B8C6-CBD964A7C438Q33906513-030C69A6-6E8B-4E29-A03E-AC588A13EF45Q33988237-4183BA1D-6063-4052-ABD4-43F3A4E4E0B7Q34222628-6D035059-9163-4354-A238-22D7DD018AB3Q34324972-E49C1D2A-E871-4C68-870E-E871389E8D80Q34394631-CB732D8A-B6D2-4024-9D1C-B617B689980AQ34521150-3F67C1ED-3E3A-49A3-8C21-DB7700281EAFQ34973846-7DF0BA53-70F7-433D-8DBF-9EA7E52D0167Q35046681-7476EA2B-4755-47CA-811F-23A85C22DF73Q35070043-39C3A9A2-3C6B-498B-8B6B-A37997E66BCAQ35171897-C9DD6D5A-C1CF-4F7E-B9B7-02A22154609DQ35174785-84936B1C-66F0-4FFE-8CF6-EA33F9871D0EQ35185890-DCEE02D7-2B9F-41A4-AA18-C193976C6D8BQ35199381-FBF5458D-8444-4293-BD64-7B38FE61A739
P2860
Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@ast
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@en
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@nl
type
label
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@ast
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@en
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@nl
prefLabel
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@ast
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@en
Mcm4,6,7 uses a "pump in ring" ...... ly translocate along a duplex.
@nl
P2860
P921
P356
P1476
Mcm4,6,7 uses a "pump in ring" ...... ely translocate along a duplex
@en
P2093
Megan J Davey
P2860
P304
49171-49182
P356
10.1074/JBC.M308074200
P407
P577
2003-09-17T00:00:00Z