Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex
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Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcriptionPhosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 bindingAnalysis of phosphorylation of human heat shock factor 1 in cells experiencing a stressXenobiotic perturbation of ER stress and the unfolded protein responsePleiotropic role of HSF1 in neoplastic transformationHeat shock transcription factor 1 as a therapeutic target in neurodegenerative diseasesImmunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activatorThe heat shock protein/chaperone network and multiple stress resistanceDAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activityHSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivoCoactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shockA comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substratesCHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70The identification of protein kinase C iota as a regulator of the Mammalian heat shock response using functional genomic screensClient Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted MutantsA novel role for the immunophilin FKBP52 in copper transportDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMHeat shock proteins: cellular and molecular mechanisms in the central nervous system.Heat shock-independent induction of multidrug resistance by heat shock factor 1.To fold or not to fold: modulation and consequences of Hsp90 inhibition.Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids.On mechanisms that control heat shock transcription factor activity in metazoan cells.Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.mTORC1 links protein quality and quantity control by sensing chaperone availability.Protein folding in the cytoplasm and the heat shock response.Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.Differential activation of Toll-like receptor-mediated apoptosis induced by hypoxiaATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells.Heat shock proteins as emerging therapeutic targets.Regulation of survival gene hsp70.Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desertZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia.Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1.NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.Heat shock factors: integrators of cell stress, development and lifespan.Dual functions of the ZmCCT-associated quantitative trait locus in flowering and stress responses under long-day conditions.
P2860
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P2860
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex
description
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im Dezember 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/12/07)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/12/07)
@nl
наукова стаття, опублікована в грудні 2001
@uk
name
Evidence for a mechanism of re ...... ty by a multichaperone complex
@ast
Evidence for a mechanism of re ...... ty by a multichaperone complex
@en
Evidence for a mechanism of re ...... ty by a multichaperone complex
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type
label
Evidence for a mechanism of re ...... ty by a multichaperone complex
@ast
Evidence for a mechanism of re ...... ty by a multichaperone complex
@en
Evidence for a mechanism of re ...... ty by a multichaperone complex
@nl
prefLabel
Evidence for a mechanism of re ...... ty by a multichaperone complex
@ast
Evidence for a mechanism of re ...... ty by a multichaperone complex
@en
Evidence for a mechanism of re ...... ty by a multichaperone complex
@nl
P2093
P3181
P356
P1476
Evidence for a mechanism of re ...... ty by a multichaperone complex
@en
P2093
D. F. Smith
D. O. Toft
F. Boellmann
R. Voellmy
T. Guettouche
W. B. Pratt
P304
45791–45799
P3181
P356
10.1074/JBC.M105931200
P407
P577
2001-12-07T00:00:00Z