Interactions of fibrillin-1 with heparin/heparan sulfate, implications for microfibrillar assembly
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Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndromeHeparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assemblyHuman eye development is characterized by coordinated expression of fibrillin isoformsFunctional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastinThe molecular genetics of Marfan syndrome and related disordersAbsence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patientsGenetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and functionStructure of the Fibrillin-1 N-Terminal Domains Suggests that Heparan Sulfate Regulates the Early Stages of Microfibril AssemblyADAMTS proteins as modulators of microfibril formation and functionFibrillin-1 directly regulates osteoclast formation and function by a dual mechanismCell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrinsADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formationDisruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiationDecorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycinEnhanced expression of fibrillin-1, a constituent of the myocardial extracellular matrix in fibrosisAdamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasiaTissue elasticity and the ageing elastic fibre.Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.Defining elastic fiber interactions by molecular fishing: an affinity purification and mass spectrometry approach.Biogenesis and function of fibrillin assemblies.Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathyFibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts.C-terminal propeptide is required for fibrillin-1 secretion and blocks premature assembly through linkage to domains cbEGF41-43.Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc.Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactionsThe heparin-binding activity of secreted modular calcium-binding protein 1 (SMOC-1) modulates its cell adhesion propertiesFibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.Homocysteine modifies structural and functional properties of fibronectin and interferes with the fibronectin-fibrillin-1 interaction.Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injurySustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes.ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesisComplex contributions of fibronectin to initiation and maturation of microfibrilsFibrillin-containing microfibrils are key signal relay stations for cell function.Biogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assemblyApplying elastic fibre biology in vascular tissue engineering.Fibrillin assembly requires fibronectin.Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimersADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling.Vascular extracellular matrix and arterial mechanics.
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P2860
Interactions of fibrillin-1 with heparin/heparan sulfate, implications for microfibrillar assembly
description
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im September 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/09/21)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/09/21)
@nl
наукова стаття, опублікована у вересні 2001
@uk
name
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@ast
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@en
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@nl
type
label
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@ast
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@en
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@nl
prefLabel
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@ast
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@en
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@nl
P2093
P2860
P3181
P356
P1476
Interactions of fibrillin-1 wi ...... ns for microfibrillar assembly
@en
P2093
D. P. Reinhardt
K. Tiedemann
P. K. Müller
P2860
P304
36035–36042
P3181
P356
10.1074/JBC.M104985200
P407
P577
2001-09-21T00:00:00Z