Target-oriented and diversity-oriented organic synthesis in drug discovery
about
Privileged scaffolds for library design and drug discoverySynthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitorsInhaled protein/peptide-based therapies for respiratory diseaseDiversity-oriented synthetic strategies applied to cancer chemical biology and drug discoveryEvolution and applications of plant pathway resources and databasesFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityBig data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicantsChemical biology approaches for the study of apicomplexan parasitesIdentification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput ScreenStructure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alphaRecent advances in the electrochemical construction of heterocyclesIdentification of a novel retinoid by small molecule screening with zebrafish embryosIdentification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assayStatistical metamodeling for revealing synergistic antimicrobial interactionsReagent based DOS: a "Click, Click, Cyclize" strategy to probe chemical spaceTowards the optimal screening collection: a synthesis strategyDiversity-Oriented Synthesis of Natural-Product-like Libraries Containing a 3-Methylbenzofuran Moiety for the Discovery of New Chemical ElicitorsDiversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interactionKinase-Independent Small-Molecule Inhibition of JAK-STAT SignalingPIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signalingModern natural products drug discovery and its relevance to biodiversity conservationHighly stereoselective synthesis of natural-product-like hybrids by an organocatalytic/multicomponent reaction sequence.Compound library development guided by protein structure similarity clustering and natural product structureParallel and four-step synthesis of natural-product-inspired scaffolds through modular assembly and divergent cyclization.Considerations for designing chemical screening strategies in plant biology.Asymmetric Catalysis in Diversity-Oriented Organic Synthesis: Enantioselective Synthesis of 4320 Encoded and Spatially Segregated Dihydropyrancarboxamides We thank the National Institute of General Medical Sciences (GM-52067) for support of this resTowards vast libraries of scaffold-diverse, conformationally constrained oligomers.Encoded self-assembling chemical libraries.Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries.Retrovirally delivered random cyclic Peptide libraries yield inhibitors of interleukin-4 signaling in human B cells.A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators.Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers.Chemical genetics for therapeutic target mining.Chemical genetics: ligand-based discovery of gene function.Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic.Domain-based small molecule binding site annotationSolution-phase synthesis of a tricyclic pyrrole-2-carboxamide discovery library applying a stetter-Paal-Knorr reaction sequenceFluorous mixture synthesis of two libraries with hydantoin-, and benzodiazepinedione-fused heterocyclic scaffolds.
P2860
Q24604575-6FC8045E-B707-44D2-8A90-8CAFC7CCA63FQ24648361-F4E15502-CCD3-4876-996F-5ADFFE777781Q26751439-16F7FA3D-90A6-4E34-8AC5-2B776DEDBAC3Q26829081-7EBF799B-62EF-4BC5-AC96-3873281FB62AQ26865772-A0F8CA3F-EF28-444B-BC77-B112DE0ED85DQ26996645-CE6021C1-9EEA-42D0-BB52-7E7B9B427B68Q27008504-88E1937A-657D-4E40-AC0C-5ABD584F7DD3Q27025364-F1ED5DFF-2CD9-4673-BBBE-562F8120229DQ27481404-1D3C2F13-8064-4ECB-AC47-C072D408A16EQ27625567-98437515-3EB3-4C34-BFA2-A89599652E47Q28080713-36919684-DEA2-46E7-94C8-BF410EADE36BQ28472496-C4F8FBA9-23D2-4E53-9E3B-7AD017A2CD66Q28476138-7064BC83-6C4A-4EAE-820C-72ADCBAF235EQ28476193-9022871B-72E0-460D-A676-BF16AD50F118Q28751421-5C7AA3B4-A9D0-4AC7-858B-60BAB2C2A9BCQ28755381-C687B19C-B60B-4667-BE55-7A5A52C1D679Q28817632-73E4D88E-B62D-4506-A826-D4F0A09A2D52Q28821081-51D26F6E-3FB2-4E6D-B877-525E5411FCD1Q28828592-034B6E9F-12B8-4013-828F-DCA9871DF952Q28833590-4DD46086-F999-416A-AD3E-9259502FAF1CQ29353836-FC0A2343-5ABD-4FAE-B61C-A7F8DE4B662FQ30316563-0BEDB5E1-30F7-4556-99F9-C72920E2998EQ30344285-68D31203-778A-40EB-B691-45A24826A216Q30394831-E349D5DC-3148-41EF-91D7-97FADF74B33EQ30636976-376BB8C9-8608-4B3C-9EF0-CC681E411F2AQ30731692-9E05FD84-D439-4D5E-B801-D95CF25F24A9Q30748083-C8A95A21-C6AE-48B1-BAAE-C406BF684E26Q30760719-B64F6103-E64C-4215-8E7D-C6E927D073B8Q30826699-141216E2-AB20-4C2C-A02A-E13E1600306CQ30841661-EDDA872B-D558-47C2-B5A0-47C92516B316Q31029855-80CB6370-8EC8-4BDC-B012-BF35F4AA5327Q31064047-ED42E75E-0F6C-426F-AA7A-4188CD3FDBA2Q31115596-7814091B-9A61-47A7-8078-5C7A78419616Q31134606-CFCEDC67-9251-4BDC-9E5C-5C873D088C94Q31881396-9BB4004B-3F3E-4D89-B670-795EF6B20109Q33224424-4BFE2382-A89F-4938-920A-A62F2D1A0638Q33234858-8AC380EF-C125-4480-8247-C9A884CC32F3Q33236886-83CF2DBF-6C5A-496C-928F-77A4AC83D6D1Q33242431-43A16785-3044-4140-917A-E726AD4439FAQ33256858-8190EC95-7DFE-4B3A-A5F3-A6472EF15CB0
P2860
Target-oriented and diversity-oriented organic synthesis in drug discovery
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մարտին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Target-oriented and diversity-oriented organic synthesis in drug discovery
@ast
Target-oriented and diversity-oriented organic synthesis in drug discovery
@en
Target-oriented and diversity-oriented organic synthesis in drug discovery
@nl
type
label
Target-oriented and diversity-oriented organic synthesis in drug discovery
@ast
Target-oriented and diversity-oriented organic synthesis in drug discovery
@en
Target-oriented and diversity-oriented organic synthesis in drug discovery
@nl
altLabel
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery
@en
prefLabel
Target-oriented and diversity-oriented organic synthesis in drug discovery
@ast
Target-oriented and diversity-oriented organic synthesis in drug discovery
@en
Target-oriented and diversity-oriented organic synthesis in drug discovery
@nl
P3181
P1433
P1476
Target-oriented and diversity-oriented organic synthesis in drug discovery
@en
P2093
S L Schreiber
P304
P3181
P356
10.1126/SCIENCE.287.5460.1964
P407
P577
2000-03-17T00:00:00Z