MDM2--master regulator of the p53 tumor suppressor protein
about
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseMDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosisA novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stabilityp53 mediates the negative regulation of MDM2 by orphan receptor TR3S100 proteins interact with the N-terminal domain of MDM2DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradationTyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulationStress-dependent nucleolin mobilization mediated by p53-nucleolin complex formationTranscriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexesHIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levelsStructural conservation of druggable hot spots in protein-protein interfacesSmall-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyA panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategiesModulation of Protein-Protein Interactions for the Development of Novel TherapeuticsThe role of p53 in cancer drug resistance and targeted chemotherapyHistone methylation modifiers in cellular signaling pathwaysBeta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damageA synthetic form of frizzled 8-associated antiproliferative factor enhances p53 stability through USP2a and MDM2Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesisMonitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid ModelSignificant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug TreatmentFGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an intracrine pathwayTumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motifTime-Dependent Regulation of Apoptosis by AEN and BAX in Response to 2-Aminoanthracene Dietary ConsumptionAmplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma.Oscillations and variability in the p53 systemFourier analysis and systems identification of the p53 feedback loopMicroarray and ChIP-seq data analysis revealed changes in p53-mediated transcriptional regulation in Nutlin-3-treated U2OS cellsComplex dynamics of transcription regulation.Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents.Elucidating the digital control mechanism for DNA damage repair with the p53-Mdm2 system: single cell data analysis and ensemble modelling.A study of T cell tolerance to the tumor-associated antigen MDM2: cytokines can restore antigen responsiveness, but not high avidity T cell functionN-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine DoubleThe p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2
P2860
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P2860
MDM2--master regulator of the p53 tumor suppressor protein
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
MDM2--master regulator of the p53 tumor suppressor protein
@ast
MDM2--master regulator of the p53 tumor suppressor protein
@en
MDM2--master regulator of the p53 tumor suppressor protein
@nl
type
label
MDM2--master regulator of the p53 tumor suppressor protein
@ast
MDM2--master regulator of the p53 tumor suppressor protein
@en
MDM2--master regulator of the p53 tumor suppressor protein
@nl
prefLabel
MDM2--master regulator of the p53 tumor suppressor protein
@ast
MDM2--master regulator of the p53 tumor suppressor protein
@en
MDM2--master regulator of the p53 tumor suppressor protein
@nl
P2093
P3181
P1433
P1476
MDM2--master regulator of the p53 tumor suppressor protein
@en
P2093
P3181
P356
10.1016/S0378-1119(99)00487-4
P407
P577
2000-01-25T00:00:00Z