Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains - sprookjes - yvandenbroek - TriplyDB

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

http://www.wikidata.org/entity/Q28144875

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Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice Metals and amyloid-beta in Alzheimer's disease Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease An overview on therapeutics attenuating amyloid β level in Alzheimer's disease: targeting neurotransmission, inflammation, oxidative stress and enhanced cholesterol levels PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates Chronic zinc exposure decreases the surface expression of NR2A-containing NMDA receptors in cultured hippocampal neurons.Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.QZ1 and QZ2: rapid, reversible quinoline-derivatized fluoresceins for sensing biological Zn(II)Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain Zn(II)-coordination modulated ligand photophysical processes - the development of fluorescent indicators for imaging biological Zn(II) ions Phosphorescent sensor for biological mobile zinc.Polymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.Meeting of the minds: metalloneurochemistry Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization.Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease.Antioxidant strategies for Alzheimer's disease.Zn(II)-Chlorido complexes of phytohormone kinetin and its derivatives modulate expression of inflammatory mediators in THP-1 cells.Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation.Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold.Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients.Copper binding in the prion protein Structurally Characterized Zn2+ Selective Ratiometric Fluorescence Probe in 100 % Water for HeLa Cell Imaging: Experimental and Computational Studies.A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc.Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer's disease neuropathology.Expression Profiling of Solute Carrier Gene Families at the Blood-CSF Barrier.CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease.Proteomics of Alzheimer's disease: understanding mechanisms and seeking biomarkers.Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls.Zinc homeostasis and neurodegenerative disorders Serum zinc in the progression of Alzheimer's disease.Therapeutics for Alzheimer's disease based on the metal hypothesis Pharmacotherapeutic targets in Alzheimer's disease Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease.Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.

P2860

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P2860

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

http://www.wikidata.org/entity/Q28144875

description

2000 nî lūn-bûn

@nan

2000 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հունվարին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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Histochemically-reactive zinc ...... of Alzheimer's diseased brains

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C J Frederickson

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D S Silva

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G Danscher

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K B Jensen

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M S Jensen

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274-8

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Alzheimer's disease