Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells - sprookjes - yvandenbroek - TriplyDB

Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells

Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells

http://www.wikidata.org/entity/Q28187403

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Red maca (Lepidium meyenii) reduced prostate size in rats Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis 3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay Molecular and biochemical effects of a kola nut extract on androgen receptor-mediated pathways.Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane.Recent progress on nutraceutical research in prostate cancer.Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders.A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer.Novel targets for prostate cancer chemoprevention.Safety and tolerability of DIM-based therapy designed as personalized approach to reverse prostatic intraepithelial neoplasia (PIN).Multiple therapeutic and preventive effects of 3,3'-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia.Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells.Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells.Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR.Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer.Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients First results of the double-blind randomized placebo-controlled multicenter clinical trial of DIM-based therapy designed as personalized approach to reverse prostatic intraepithelial neoplasia (PIN)5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells.Antioxidant function of isoflavone and 3,3'-diindolylmethane: are they important for cancer prevention and therapy?Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs.Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects.Mechanisms and therapeutic implications of cell death induction by indole compounds.Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention.Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain.DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism.Cellular signaling perturbation by natural products.Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner.Microwave-assisted, one-pot reaction of 7-azaindoles and aldehydes: a facile route to novel di-7-azaindolylmethanes.Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics.Minireview: modulation of hormone receptor signaling by dietary anticancer indoles.Targeting NR4A1 (TR3) in cancer cells and tumors Potential targets in the discovery of new hair growth promoters for androgenic alopecia.An Update on Potential Perspectives of Glucosinolates on Protection against Microbial Pathogens and Endocrine Dysfunctions in Humans.Red Maca (Lepidium meyenii) did not affect cell viability despite increased androgen receptor and prostate-specific antigen gene expression in the human prostate cancer cell line LNCaP.Epigenetic and miRNAs Dysregulation in Prostate Cancer: The role of Nutraceuticals.Indole-3-Carbinol and Its Role in Chronic Diseases.

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P2860

Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells

http://www.wikidata.org/entity/Q28187403

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2003 nî lūn-bûn

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2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

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name

Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Journal of Biological Chemistry

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Plant-derived 3,3'-Diindolylme ...... in human prostate cancer cells

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Charlene M Schaldach

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Gary L Firestone

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Hien T Le

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Leonard F Bjeldanes

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P2860

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

Brassica vegetables and breast cancer risk

Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

Diet and its preventive role in prostatic disease.

Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor.

Subcellular steroid/nuclear receptor dynamics.

Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence.

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21136-45

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scholarly article

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2511327

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10.1074/JBC.M300588200

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23

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278

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12665522

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