The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors
about
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerGrb2-associated binding (Gab) proteins in hematopoietic and immune cell biologyGAB2--a scaffolding protein in cancerFunctions and regulation of circular dorsal rufflesOncogenic Signaling Adaptor ProteinsGab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-KitThe Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer's diseaseThe Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancerNovel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cellsT-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiationGab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motilityThe landscape of somatic copy-number alteration across human cancers.Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.Identification of GRB2 and GAB1 coexpression as an unfavorable prognostic factor for hepatocellular carcinoma by a combination of expression profile and network analysis.A transgenic Drosophila model demonstrates that the Helicobacter pylori CagA protein functions as a eukaryotic Gab adaptor.Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.The Scaffolding Protein, Grb2-associated Binder-1, in Skeletal Muscles and Terminal Schwann Cells Regulates Postnatal Neuromuscular Synapse Maturation.Role of phosphatidylinositol 3-kinase in friend spleen focus-forming virus-induced erythroid disease.Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathwayIdentification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).Gene expression analysis of mammary tissue during fetal bud formation and growth in two pig breeds--indications of prenatal initiation of postnatal phenotypic differencesA germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.Signaling through receptors and scaffolds: independent interactions reduce combinatorial complexityFlow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells.Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains.Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesisLessons in signaling and tumorigenesis from polyomavirus middle T antigen.c-Jun N-terminal Kinase 2 Regulates Multiple Receptor Tyrosine Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis.Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.Down-regulation of Gab1 inhibits cell proliferation and migration in hilar cholangiocarcinomaGab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.Interaction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathwayGab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.Abnormal hematopoiesis in Gab2 mutant miceBlocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes.Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells.Enhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1.Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes.
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P2860
The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors
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2003 nî lūn-bûn
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2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
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2003年論文
@zh-hant
2003年論文
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2003年論文
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2003年論文
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2003年论文
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name
The role of Gab family scaffol ...... ne and growth factor receptors
@ast
The role of Gab family scaffol ...... ne and growth factor receptors
@en
The role of Gab family scaffol ...... ne and growth factor receptors
@nl
type
label
The role of Gab family scaffol ...... ne and growth factor receptors
@ast
The role of Gab family scaffol ...... ne and growth factor receptors
@en
The role of Gab family scaffol ...... ne and growth factor receptors
@nl
prefLabel
The role of Gab family scaffol ...... ne and growth factor receptors
@ast
The role of Gab family scaffol ...... ne and growth factor receptors
@en
The role of Gab family scaffol ...... ne and growth factor receptors
@nl
P2860
P3181
P1433
P1476
The role of Gab family scaffol ...... ne and growth factor receptors
@en
P2093
Keigo Nishida
Toshio Hirano
P2860
P304
P3181
P356
10.1111/J.1349-7006.2003.TB01396.X
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P577
2003-12-01T00:00:00Z