Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes
about
Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferasesAdvances in kinetic isotope effect measurement techniques for enzyme mechanism studyElucidation of Enzymatic Mechanism of Phenazine Biosynthetic Protein PhzF Using QM/MM and MD SimulationsAn ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for Helicobacter pyloriRational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product ComplexGround-State Electronic Destabilization via Hyperconjugation in Aspartate AminotransferaseStructural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium TuberculosisA structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA.Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl CarbasugarsDesign of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase.Computational protein engineering: bridging the gap between rational design and laboratory evolution.Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion.Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidasesTransition states of native and drug-resistant HIV-1 protease are the same.Potent inhibition of the C-P lyase nucleosidase PhnI by Immucillin-A triphosphate.Isotope effects as probes for enzyme catalyzed hydrogen-transfer reactions.Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme.Tight binding enantiomers of pre-clinical drug candidates.Heavy atom labeled nucleotides for measurement of kinetic isotope effectsKinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building BlocksMass Modulation of Protein Dynamics Associated with Barrier Crossing in Purine Nucleoside Phosphorylase.Human DNMT1 transition state structure.Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases.DNA cytosine methylation: structural and thermodynamic characterization of the epigenetic marking mechanism.The antifolatesRational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts.Structure-function relationships of membrane-associated GT-B glycosyltransferases.Kinetic isotope effects as a probe of hydrogen transfers to and from common enzymatic cofactorsδ-Deuterium isotope effects as probes for transition-state structures of isoprenoid substrates.Artificial enzymes based on supramolecular scaffolds.Transition States, analogues, and drug development.Emerging themes in the computational design of novel enzymes and protein-protein interfaces.8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research.Glycosynthesis in a waterworld: new insight into the molecular basis of transglycosylation in retaining glycoside hydrolases.
P2860
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P2860
Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimes
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@ast
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@en
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@nl
type
label
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@ast
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@en
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@nl
prefLabel
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@ast
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@en
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@nl
P2860
P3181
P1476
Enzymatic transition states, t ...... thermodynamics, and lifetimes
@en
P2093
Vern L Schramm
P2860
P304
P3181
P356
10.1146/ANNUREV-BIOCHEM-061809-100742
P407
P577
2011-01-01T00:00:00Z