Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin - sprookjes - yvandenbroek - TriplyDB

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

http://www.wikidata.org/entity/Q28247829

about

Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.Approaches of targeting Rho GTPases in cancer drug discovery Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation MicroRNA-200b suppresses arsenic-transformed cell migration by targeting protein kinase Cα and Wnt5b-protein kinase Cα positive feedback loop and inhibiting Rac1 activation MicroRNA-200b targets protein kinase Cα and suppresses triple-negative breast cancer metastasis Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structure Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development.Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration.Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye.Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse.Rac signaling in breast cancer: a tale of GEFs and GAPs.Targeting of Rac GTPases blocks the spread of intact human breast cancer.Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility.Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.Role of small GTPase Rho in regulating corneal epithelial wound healing.Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.Inhibition and termination of physiological responses by GTPase activating proteins.β3-chimaerin, a novel member of the chimaerin Rac-GAP family.Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α.Inhibition of autophagy induced by PTEN loss promotes intrinsic breast cancer resistance to trastuzumab therapy.PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis.Protein kinase C in cancer: The top five unanswered questions.Antiproliferative and survival properties of PMA in MCF-7 breast cancer cell.Rho GTPases as therapeutic targets in cancer (Review).The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses.Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells.Assessment of Jatropha curcas L. biodiesel seed cake toxicity using the zebrafish (Danio rerio) embryo toxicity (ZFET) test.Rac-dependent doubling of HeLa cell area and impairment of cell migration and cell cycle by compounds from Iris germanica.

P2860

Q24319008-5D28D75A-7ACD-4DA1-9E0D-E5C260A5125C Q24537669-8D7174D1-8978-4D0F-81C1-4098BC910137 Q26851300-BEA14B08-5B52-49E4-AC56-BE4295B5D36D Q30009858-72377A4A-8267-4301-AD65-654404AB2D36 Q31140123-8CDFC620-DC79-4626-A06B-9947E75869AA Q33883417-351F3220-5821-4204-B733-E7C4C36E0963 Q34073967-59DA9A2D-A8F8-4BB2-A2C1-41FEF749125C Q34260220-21FD58C1-05C1-4E8B-9CF8-9157A576A081 Q34533478-2B561F3B-08EF-420E-8645-97CC4D2F835A Q34571293-466F3B69-DC26-4328-AF95-808F2C66F731 Q34600164-2572D618-F550-42C4-8FDC-9010CE833EBB Q35000289-3599D7D0-F317-412A-AB10-11AEAD4D3FA6 Q35010997-15A66078-280F-44C0-B7AD-6A4A6E6A18BE Q35287780-D6B6BDB5-04C0-4C37-A027-E84B2268D2F9 Q35758652-9DBA2044-B5F3-4785-ADF5-03F740FE883B Q35783149-03888873-11BD-4D05-B2A3-FC9E40114F74 Q35854151-E3DA766B-48C4-4CF3-B051-124B89D23904 Q36234042-61835938-D0BF-40E3-ADB8-AD32F9DD2F43 Q36356185-5547306B-05FF-4C6B-979C-3A1A048DC741 Q36776754-6ED65B2C-89BE-4226-9BB1-4ADFFC4F502B Q37140970-326AD331-ADDC-4DC5-AEC5-190C4A53A01A Q37143866-75868765-6110-4102-B853-54E2E8FEA75C Q37317542-6954E013-73B7-4E19-93B6-E1B4A6AEE315 Q37373801-84FEB567-C05A-431F-9947-3BE094BBB71C Q37980724-7F3FABD7-E467-482C-BDE9-46E67F71ECC8 Q38558388-478968A2-2326-4775-AB32-D01DED206A60 Q38770505-4D11F7D7-73B0-48FE-8301-678E8B17D290 Q38819839-CBC2A1E5-B91C-44E1-B101-717F4473F286 Q38869707-E1E3D527-0057-4977-A63D-FEB2D21F9990 Q39098659-1D7B800E-01F7-4794-B797-7D4669DADCAC Q40027479-6921651F-C9D9-4590-A256-5C05210A93FD Q41387997-22F5B40E-BDAB-4506-9798-6578F719A1A2 Q42498482-430D8459-D522-433F-9582-4091521EFC95 Q43069129-B33B78E2-F70E-4744-A6F7-558FEBD3589E Q43311930-F26C34CE-0584-47A5-972C-A90178D63DFE Q52606534-9E5BA4C0-3E90-4034-88F5-C7B764360069

P2860

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

http://www.wikidata.org/entity/Q28247829

description

2005 nî lūn-bûn

@nan

2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@ast

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@en

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@nl

type

label

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@ast

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@en

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@nl

prefLabel

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@ast

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@en

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@nl

P1433

Q28247829-C87B8BCD-2F60-4D93-A63B-9C804015DF98

P1476

Q28247829-AE13B7B7-A920-4E4D-AFAC-68FBDD610202

P2093

Q28247829-2D4DFD41-3F7C-47F1-914F-D28334727664

Q28247829-4A8A1F64-FB0E-4A18-AA06-A8CCB7C9775B

Q28247829-4F52632A-C6D6-449D-82EC-CAFDD7901599

Q28247829-8E1E94C5-07C7-400C-A2AF-568B86EA2A40

P2860

Q28247829-03DA6343-93A0-4A34-BE3E-B3A552A19874

Q28247829-08214D48-CAFF-4A61-83E3-416B72ECF187

Q28247829-189FF7AC-20A4-4A05-98D9-50C686C62FBA

Q28247829-21E4704C-8D7C-4313-A355-0AE9D9FBE45A

Q28247829-22D2E566-C5C0-4B4F-BB99-F77437DA5168

Q28247829-2313CAC1-0DC1-4C73-9F2D-1C6F2F33362A

Q28247829-29BD11ED-FA8B-479E-87F6-AB1009F3A92E

Q28247829-2B610558-4C53-474C-813D-05DD5966D10E

Q28247829-3532E463-D09C-41C0-88DC-EC2BDE40F649

Q28247829-371777C6-716B-44D3-9774-4731991CF6AF

P304

Q28247829-5B945CB2-04D3-4964-9631-4E0E82FE7D4D

P31

Q28247829-D3054D11-A799-4285-96AD-9694D4B8067F

P3181

Q28247829-3DB73FBB-0346-47F3-88F2-7424123B1929

P356

Q28247829-B1DE231D-0B0A-4C5F-91D7-E106574F1BDC

P407

Q28247829-194C75BF-5CBB-4858-BBF9-8EB9C39383AB

P433

Q28247829-2DA2417C-222F-49F3-889C-A9E5E52662CA

P478

Q28247829-32D8E4ED-696A-44EC-A51B-5991EF3FC530

P50

Q28247829-1950F555-831B-4854-9CF8-EE7D2E890D97

P577

Q28247829-17236E19-8F64-47C1-933A-40D204633555

P698

Q28247829-A378B447-7BFB-446F-9D5F-3CA048D5F1C4

P3181

P356

P1433

Journal of Biological Chemistry

P1476

Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin

@en

P2093

Chengfeng Yang

http://www.w3.org/2001/XMLSchema#string

Federico Coluccio Leskow

http://www.w3.org/2001/XMLSchema#string

Marcelo G Kazanietz

http://www.w3.org/2001/XMLSchema#string

Ying Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Binding of GAP to activated PDGF receptors

Bcr encodes a GTPase-activating protein for p21rac

Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain

Rho GTPases and the actin cytoskeleton

Rho GTPases in cell biology

P21-activated kinases in human cancer

Chimaerins, novel non-protein kinase C phorbol ester receptors, associate with Tmp21-I (p23): evidence for a novel anchoring mechanism involving the chimaerin C1 domain

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

P304

24363-70

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4912728

http://www.w3.org/2001/XMLSchema#string

P356

10.1074/JBC.M411629200

http://www.w3.org/2001/XMLSchema#string

P407

P433

26

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P50

Valerie M Weaver

P577

2005-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15863513

http://www.w3.org/2001/XMLSchema#string