Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations

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http://www.wikidata.org/entity/Q28259965

Q28259965

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Lacritin and the tear proteome as natural replacement therapy for dry eye Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease Mitochondrial function and redox control in the aging eye: role of MsrA and other repair systems in cataract and macular degenerations Macular degeneration: recent advances and therapeutic opportunities.Extracellular matrix molecules: potential targets in pharmacotherapy.The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane.The bone marrow-derived human mesenchymal stem cell: potential progenitor of the endometrial stromal fibroblast.Unraveling the mechanism of elastic fiber assembly: The roles of short fibulins Comparison of drusen and modifying genes in autosomal dominant radial drusen and age-related macular degeneration.Fibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas.Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.Epigenetic inactivation of EFEMP1 is associated with tumor suppressive function in endometrial carcinoma.Interaction of complement factor h and fibulin3 in age-related macular degeneration Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration.Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.Advances in urinary protein biomarkers for urogenital and non-urogenital pathologies.Hypertensive vascular remodeling was inhibited by Xuezhikang through the regulation of Fibulin-3 and MMPs in spontaneously hypertensive rats EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway.A local complement response by RPE causes early-stage macular degeneration.Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis.Characterization of the gelatinase system of the laminar human optic nerve, and surrounding annulus of Bruch's membrane, choroid, and sclera.A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene.HEMICENTIN-1 (FIBULIN-6) and the 1q31 AMD locus in the context of complex disease: review and perspective.Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes.A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia.Clinical disorders affecting mesopic vision.Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 expression and regulation in uterine leiomyoma.Fibulin-3 may improve vascular health through inhibition of MMP-2/9 and oxidative stress in spontaneously hypertensive rats.Vascular endothelial growth factor in eye disease.Decrease of fibulin-3 in hepatocellular carcinoma indicates poor prognosis.Failure of pelvic organ support in mice deficient in fibulin-3.EFEMP1 is repressed by estrogen and inhibits the epithelial-mesenchymal transition via Wnt/β-catenin signaling in endometrial carcinoma.Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration.Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin Age-related macular degeneration and changes in the extracellular matrix.

P2860

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P2860

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations

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