about
Novel myosin-based therapies for congenital cardiac and skeletal myopathiesRationally engineered Troponin C modulates in vivo cardiac function and performance in health and diseaseCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeNovel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.Controlled Heat Stress Promotes Myofibrillogenesis during MyogenesisInstrumentation to study myofibril mechanics from static to artificial simulations of cardiac cycle.High throughput physiological screening of iPSC-derived cardiomyocytes for drug development.Sarcomere neutralization in inherited cardiomyopathy: small-molecule proof-of-concept to correct hyper-Ca2+-sensitive myofilamentsA post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylationDesigning proteins to combat disease: Cardiac troponin C as an example.Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish.Therapeutic Strategies Targeting Inherited Cardiomyopathies.Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog.Top-Down Targeted Proteomics Reveals Decrease in Myosin Regulatory Light-Chain Phosphorylation That Contributes to Sarcopenic Muscle Dysfunction.In silico identification of rescue sites by double force scanning.'(De-)sensitization' vs. 'Uncoupling': what drives cardiomyopathies in the thin filament? Reply.Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil.Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20.Chaperones and the Proteasome System: Regulating the Construction and Demolition of Striated Muscle.The potential of obscurin as a therapeutic target in muscle disorders.Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.Right Ventricular Myofilament Functional Differences in Humans with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension.Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin.Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype.Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Targeting the sarcomere to correct muscle function
@ast
Targeting the sarcomere to correct muscle function
@en
Targeting the sarcomere to correct muscle function
@nl
type
label
Targeting the sarcomere to correct muscle function
@ast
Targeting the sarcomere to correct muscle function
@en
Targeting the sarcomere to correct muscle function
@nl
prefLabel
Targeting the sarcomere to correct muscle function
@ast
Targeting the sarcomere to correct muscle function
@en
Targeting the sarcomere to correct muscle function
@nl
P2860
P3181
P356
P1476
Targeting the sarcomere to correct muscle function
@en
P2093
Brian D Sykes
Peter M Hwang
P2860
P2888
P304
P3181
P356
10.1038/NRD4554
P407
P577
2015-05-01T00:00:00Z
P6179
1036573195