The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites
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Structure of the Type III Pantothenate Kinase from Bacillus anthracis at 2.0 Å Resolution: Implications for Coenzyme A-Dependent Redox Biology † , ‡Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorderLocation and conformation of pantothenate and its derivatives in Mycobacterium tuberculosis pantothenate kinase: insights into enzyme actionStructural and Biochemical Characterization of Compounds Inhibiting Mycobacterium tuberculosis Pantothenate KinaseCrystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N-substituted pantothenamidesCrystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteriaPantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus.Antibacterial activity of N-pentylpantothenamide is due to inhibition of coenzyme a synthesisPantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivatedSynthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferaseExploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase.The structure at 1.7 A resolution of the protein product of the At2g17340 gene from Arabidopsis thalianaBiosynthesis of Pantothenic Acid and Coenzyme A.Chemical biology tools to study pantetheinases of the vanin family.Antibiotic evaluation and in vivo analysis of alkynyl Coenzyme A antimetabolites in Escherichia coli.Functional contribution of a conserved, mobile loop histidine of phosphoribulokinase.Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites.A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis.Role of prokaryotic type I and III pantothenate kinases in the coenzyme A biosynthetic pathway of Bacillus subtilis.Screening, identification, and characterization of mechanistically diverse inhibitors of the Mycobacterium tuberculosis enzyme, pantothenate kinase (CoaA).
P2860
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P2860
The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites
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2004 nî lūn-bûn
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2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2004 թվականի օգոստոսին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年论文
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name
The structure of the pantothen ...... regulator, and antimetabolites
@ast
The structure of the pantothen ...... regulator, and antimetabolites
@en
The structure of the pantothen ...... regulator, and antimetabolites
@nl
type
label
The structure of the pantothen ...... regulator, and antimetabolites
@ast
The structure of the pantothen ...... regulator, and antimetabolites
@en
The structure of the pantothen ...... regulator, and antimetabolites
@nl
prefLabel
The structure of the pantothen ...... regulator, and antimetabolites
@ast
The structure of the pantothen ...... regulator, and antimetabolites
@en
The structure of the pantothen ...... regulator, and antimetabolites
@nl
P2093
P2860
P50
P356
P1476
The structure of the pantothen ...... regulator, and antimetabolites
@en
P2093
Charles O Rock
Hee-Won Park
Kristopher G Virga
Robert A Ivey
Yong-Mei Zhang
P2860
P304
P356
10.1074/JBC.M403152200
P407
P577
2004-08-20T00:00:00Z