Nonsense-mediated mRNA decay: terminating erroneous gene expression
about
Non-coding RNA: what is functional and what is junk?EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness.Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decayHuman INT6/eIF3e is required for nonsense-mediated mRNA decayLoss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defectsMutations of human NARS2, encoding the mitochondrial asparaginyl-tRNA synthetase, cause nonsyndromic deafness and Leigh syndromel7Rn6 encodes a novel protein required for clara cell function in mouse lung developmentLoss-of-function mutations in euchromatin histone methyl transferase 1 (EHMT1) cause the 9q34 subtelomeric deletion syndromeStructures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complexA view to a kill: structure of the RNA exosome.Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cellsProteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systemsSingle molecule fluorescence approaches shed light on intracellular RNAsSkipping of exons by premature termination of transcription and alternative splicing within intron-5 of the sheep SCF gene: a novel splice variantThe spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8.Selection for reduced translation costs at the intronic 5' end in fungiStructural and functional insights into the human Upf1 helicase coreRNA polymerase II subunit Rpb9 is important for transcriptional fidelity in vivoRole for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay.Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stabilityTargeting of aberrant mRNAs to cytoplasmic processing bodies.Opportunities for immunotherapy in microsatellite instable colorectal cancerThe archaeal exosome core is a hexameric ring structure with three catalytic subunitsDiversity of the Genes Implicated in Algerian Patients Affected by Usher SyndromeIdentification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in ratsIdentification and characterization of novel genotoxic stress-inducible nuclear long noncoding RNAs in mammalian cellsCombination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritisA naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia.Tailoring of membrane proteins by alternative splicing of pre-mRNA.Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapmentA high density of ancient spliceosomal introns in oxymonad excavates.Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.Intron mis-splicing: no alternative?Conflicting selection pressures on synonymous codon use in yeast suggest selection on mRNA secondary structuresMutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.Mutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansGenome-wide identification and characterization of cytochrome P450 monooxygenase genes in the ciliate Tetrahymena thermophila.Relaxed functional constraints on triplicate α-globin gene in the bank vole suggest a different evolutionary history from other rodents.A critical analysis of Atoh7 (Math5) mRNA splicing in the developing mouse retina.A global comparison between nuclear and cytosolic transcriptomes reveals differential compartmentalization of alternative transcript isoforms.
P2860
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P2860
Nonsense-mediated mRNA decay: terminating erroneous gene expression
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@ast
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@en
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@nl
type
label
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@ast
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@en
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@nl
prefLabel
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@ast
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@en
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@nl
P3181
P1476
Nonsense-mediated mRNA decay: terminating erroneous gene expression
@en
P2093
Kristian E Baker
Roy Parker
P3181
P356
10.1016/J.CEB.2004.03.003
P407
P577
2004-06-01T00:00:00Z