Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis
about
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinaseThe extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand.Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2Structural analysis of an epidermal growth factor/transforming growth factor-alpha chimera with unique ErbB binding specificityHuman cancer protein-protein interaction network: a structural perspectiveEGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammalsRandomization of the receptor alpha chain recruitment epitope reveals a functional interleukin-5 with charge depletion in the CD loop.Selective formation of ErbB-2/ErbB-3 heterodimers depends on the ErbB-3 affinity of epidermal growth factor-like ligands.Coiled coil miniprotein randomization on phage leads to charge pattern mimicry of the receptor recognition determinant of interleukin 5.Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display.A general method for greatly improving the affinity of antibodies by using combinatorial librariesA genetic screen for anchorage-independent proliferation in mammalian cells identifies a membrane-bound neuregulin.Identification of mTORC2 as a necessary component of HRG/ErbB2-dependent cellular transformationA potent anti-HB-EGF monoclonal antibody inhibits cancer cell proliferation and multiple angiogenic activities of HB-EGFInhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3.High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin DomainsHigher-order association states of cellular ERBB3 probed with photo-cross-linkable aptamers.A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation.Inactivation of neuregulin-1 by nitration.Five carboxyl-terminal residues of neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase.Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.Analysis of heregulin symmetry by weighted evolutionary tracing.Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation.Role of the C-terminal linear region of EGF-like growth factors in ErbB specificity.Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival.Epitope randomization redefines the functional role of glutamic acid 110 in interleukin-5 receptor activation.
P2860
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P2860
Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Binding interaction of the her ...... y alanine scanning mutagenesis
@ast
Binding interaction of the her ...... y alanine scanning mutagenesis
@en
Binding interaction of the her ...... y alanine scanning mutagenesis
@nl
type
label
Binding interaction of the her ...... y alanine scanning mutagenesis
@ast
Binding interaction of the her ...... y alanine scanning mutagenesis
@en
Binding interaction of the her ...... y alanine scanning mutagenesis
@nl
prefLabel
Binding interaction of the her ...... y alanine scanning mutagenesis
@ast
Binding interaction of the her ...... y alanine scanning mutagenesis
@en
Binding interaction of the her ...... y alanine scanning mutagenesis
@nl
P2093
P2860
P356
P1476
Binding interaction of the her ...... y alanine scanning mutagenesis
@en
P2093
J A Lofgren
M D Ballinger
M X Sliwkowski
P I Pisacane
V D Fitzpatrick
W J Fairbrother
P2860
P304
P356
10.1074/JBC.273.19.11667
P407
P577
1998-05-08T00:00:00Z