TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing
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Molecular mechanism of oxidation-induced TDP-43 RRM1 aggregation and loss of functionUbiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolinesTARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALSExpanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALSStructural insights into TDP-43 in nucleic-acid binding and domain interactionsTDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicingPrion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative diseasePathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disordersiPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease DevelopmentNeuronal RNA-binding proteins in health and diseaseHyperphosphorylation as a defense mechanism to reduce TDP-43 aggregationTDP-43 aggregation in neurodegeneration: are stress granules the key?TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Emerging mechanisms of molecular pathology in ALSSumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifsTDP-43 mutations in familial and sporadic amyotrophic lateral sclerosisIdentification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexesTar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissueTDP-43 identified from a genome wide RNAi screen for SOD1 regulatorsThe tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43β-amyloid triggers ALS-associated TDP-43 pathology in AD modelsAmyotrophic lateral sclerosis multiprotein biomarkers in peripheral blood mononuclear cellsTARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathyTARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosisTDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degenerationPhosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS.Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis.Association between novel TARDBP mutations and Chinese patients with amyotrophic lateral sclerosisTransgenic rat model of neurodegeneration caused by mutation in the TDP gene.
P2860
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P2860
TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@ast
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@en
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@nl
type
label
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@ast
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@en
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@nl
prefLabel
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@ast
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@en
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@nl
P2093
P921
P3181
P356
P1476
TDP-43 binds heterogeneous nuc ...... ance regulator exon 9 splicing
@en
P2093
Antonia Brindisi
Emanuele Buratti
Francisco E Baralle
Maurizio Giombi
Sergio Tisminetzky
Youhna M Ayala
P304
P3181
P356
10.1074/JBC.M505557200
P407
P577
2005-11-11T00:00:00Z