Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
about
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesisHuman disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein bindingCraniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acidCrystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificityActivating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cellsNew insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistanceInhibition of Bmp signaling affects growth and differentiation in the anagen hair follicleNoggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somiteAutosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin.The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanismsTransgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotypeSelective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitroInterplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN.Inhibitors/antagonists of TGF-β system in kidney fibrosisIs the spinal motion segment a diarthrodial polyaxial joint: what a nice nucleus like you doing in a joint like this?Interaction of TGFβ and BMP signaling pathways during chondrogenesisThe role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasisStructural basis of BMP signalling inhibition by the cystine knot protein NogginA New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP SignalIdentical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangismRole of hindbrain in inner ear morphogenesis: analysis of Noggin knockout miceNoggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complexTrps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cellsSynovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spineBMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formationGenetic evidence that SOST inhibits WNT signaling in the limbNoggin regulates Bmp4 activity during pituitary inductionWnt/beta-catenin signaling is sufficient and necessary for synovial joint formationDevelopmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signalingEpimorphin expression in intestinal myofibroblasts induces epithelial morphogenesisThe zinc finger transcription factors Osr1 and Osr2 control synovial joint formationMutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGINRegulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathwaysThe transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6Digit patterning during limb development as a result of the BMP-receptor interactionPerspectives on hyperphalangy: patterns and processesDevelopmental regulation of the growth plateNoggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation.Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State.
P2860
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P2860
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
description
1998 nî lūn-bûn
@nan
1998 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@ast
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@en
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@nl
type
label
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@ast
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@en
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@nl
prefLabel
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@ast
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@en
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@nl
P2093
P3181
P1433
P1476
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
@en
P2093
A P McMahon
J A McMahon
L J Brunet
R M Harland
P304
P3181
P356
10.1126/SCIENCE.280.5368.1455
P407
P577
1998-05-29T00:00:00Z