The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia - sprookjes - yvandenbroek - TriplyDB

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

http://www.wikidata.org/entity/Q28272266

about

Insomnia pharmacotherapy The hypocretin/orexin system in sleep disorders: preclinical insights and clinical progress Physiology of the orexinergic/hypocretinergic system: a revisit in 2012 Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators Evaluation of potential PET imaging probes for the orexin 2 receptors.Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.Quantitative proteomics in laser capture microdissected sleep nuclei from rat brain.Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects.Suvorexant for the treatment of insomnia.The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.A Phase II Dose-Ranging Study Evaluating the Efficacy and Safety of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Primary Insomnia.Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.Orexin receptor antagonists as therapeutic agents for insomnia Discovery and development of orexin receptor antagonists as therapeutics for insomnia.Orexin 1 receptor antagonists in compulsive behavior and anxiety: possible therapeutic use.Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism.Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder.Orexin OX2 Receptor Antagonists as Sleep Aids.Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist.Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain.Distinct effects of IPSU and suvorexant on mouse sleep architecture.Orexin research: patent news from 2016.The Molecular Basis of Insomnia: Implication for Therapeutic Approaches.Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach.Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.Molecular Evolutionary Analysis of the HCRTR Gene Family in Vertebrates.Orexin Receptor Antagonists

P2860

Q24623757-F64628C5-0A7C-42E4-A2FF-7AAD3CE923A1 Q26751277-51E2DF62-296F-42F0-AB3E-A0C9453F4451 Q26822470-3AC9F62B-D4A0-4051-BAF2-28FA76052629 Q27347707-F4754725-2923-484E-BF71-A9D443E88955 Q30375507-1EF110BA-8E8B-4EB1-9A41-516067196C50 Q30423240-69FC7315-68FF-4A67-B00A-B40DCCF24A11 Q30555478-1BC6B6DD-3C36-4DDC-B2CB-1D79EB13469A Q33645756-9F5BD381-D90F-42E5-8ED6-95A4175AA0CC Q33821949-439D8F14-5A68-4C65-A3BB-B8CD5719F0CC Q34238302-9567D997-4F86-4784-BF3E-B3AE85691B0A Q34443676-05757C2D-11EB-438C-97BF-67D6DC571EB1 Q36375246-E9C4B5FF-E320-44B1-B7EE-6FB55755A802 Q37220464-56E09DEE-3B2E-45E1-AF8A-CE165BC19A2C Q37411777-12978B99-7DD0-4F60-B1E7-31A5768FC877 Q37413138-C67AF65A-DE0E-439A-A9D0-653F73A5996D Q37522859-7A9ACEB7-E1B9-4FB3-B703-2BCA8D60980B Q37581553-5FEFB5EA-6AC7-4D36-BBFC-04DF426EEB42 Q37583131-0EF92CF6-6003-4DE0-805D-7BCBCFF0DC89 Q38108972-B46FDA51-9C93-44E1-8D82-BEF36FFCEA1F Q38743165-140A97C3-02CE-4ADA-A222-6B150ECC5D5A Q39026714-78BFA8F9-6084-4C5E-BF1D-0244439912EC Q39229046-EC8815FF-B664-4A56-80C8-B5246B00C25E Q41998350-DB8B6653-8002-4986-BE24-0317DF83FA98 Q42469028-42DE45BE-2911-4CE7-8112-1C62F00FB5B7 Q42825760-C741E8B2-A27E-4139-8DC1-C6E780629F84 Q47718610-C5A30396-1D20-491A-B009-EE716C3A5EFC Q47819498-BA51C33A-32D7-4993-B7E5-E6F29F39E54B Q47839193-59C46B14-9618-466C-AE33-3D41238D5285 Q48689667-1445D349-E17C-4604-A9B4-EFF3E60E2ABD Q55405532-8A2F940A-5384-400D-B571-0A4E9798D469 Q59201264-20E3570E-8009-4673-B59E-21E85F273E61

P2860

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

http://www.wikidata.org/entity/Q28272266

description

2012 nî lūn-bûn

@nan

2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

name

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@ast

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@en

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@nl

type

label

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@ast

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@en

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@nl

prefLabel

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@ast

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@en

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@nl

P1433

Q28272266-B74B3025-7452-4952-ABD3-C54F3703E2EB

P1476

Q28272266-0B0E1424-3A76-405D-BB9B-EF9C141A34F5

P2093

Q28272266-11ABE20C-7A7A-4509-A4D9-765A95FA51DB

Q28272266-29D7BBFD-CBE1-4AE0-9431-578815D0F227

Q28272266-34C34932-13FF-49CF-87AA-A0FAB9109808

Q28272266-48DB6C92-1181-492C-8982-5671F3172DB2

Q28272266-987240CC-0797-46F4-82EA-17DD0AC25F9C

Q28272266-CD1E0773-69E4-4544-93F0-57579C53B481

P2860

Q28272266-00984E95-16A7-4128-BA3B-3BC02213D042

Q28272266-066A9305-22C3-4723-8CFD-160AECF1BD9F

Q28272266-10B0DC02-20D5-47CE-BCFB-0B4315804093

Q28272266-1C40D565-A6C9-4D7D-9B8D-EAFB514268F7

Q28272266-47291668-399F-464D-9E1A-1E09EC45A5E3

Q28272266-473AC5EF-F3AB-432C-B6D8-7B19475A25E2

Q28272266-4A8746AE-27B2-48BF-94EF-5CB841E4E97D

Q28272266-4ABFB463-B242-4469-AEBB-708C215D87E1

Q28272266-52C4ABA0-5FC9-48E7-937B-681BFF022EBC

Q28272266-55E824B3-8D45-4C40-8AD7-1AC0C59334EF

P304

Q28272266-25B3A8E7-C81A-4575-A74C-E42AD726DA09

P31

Q28272266-8A0BA111-7227-431D-B7FF-9E02ED6E431B

P3181

Q28272266-8D681F5E-1CCA-421F-8885-1432E9139FD5

P356

Q28272266-F26261E0-F926-45EB-86E6-A83A2E528365

P407

Q28272266-7D4CF4E8-5633-407B-A79F-62AA5B6CF777

P433

Q28272266-9E0D04B5-332D-4FDE-AD0D-CD8118A0E103

P478

Q28272266-C2298372-DFF1-46A4-9072-D795C2ED0254

P577

Q28272266-52558316-03BA-4D5D-9238-FA2D16D9E371

P5875

Q28272266-669F7411-274D-407A-BEF9-E4C4D23FEE73

P698

Q28272266-15B2894C-8B36-42C5-A876-505D95B15227

P921

Q28272266-04F5AEE7-C0FD-44D4-8DA3-EC5945118E8A

Q28272266-8E76FDBC-5B89-4358-8C39-F9A1AEC4F881

P932

Q28272266-3DB4004C-F744-448B-9AC0-788FCFC36F0A

P3181

P356

P1433

P1476

The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

@en

P2093

Emiliangelo Ratti

http://www.w3.org/2001/XMLSchema#string

Gianluca Nucci

http://www.w3.org/2001/XMLSchema#string

Heidi Danker-Hopfe

http://www.w3.org/2001/XMLSchema#string

Lisa Squassante

http://www.w3.org/2001/XMLSchema#string

Paolo Bettica

http://www.w3.org/2001/XMLSchema#string

Stefano Zamuner

http://www.w3.org/2001/XMLSchema#string

P2860

Meta-analysis of benzodiazepine use in the treatment of insomnia

Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist

Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia

Disposition and metabolism of [14C]SB-649868, an orexin 1 and 2 receptor antagonist, in humans

Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery

Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

The memory function of sleep

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.

P304

1097-104

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1053561

http://www.w3.org/2001/XMLSchema#string

P356

10.5665/SLEEP.1996

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

35

http://www.w3.org/2001/XMLSchema#string

P577

2012-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230593117

http://www.w3.org/2001/XMLSchema#string

P698

22851805

http://www.w3.org/2001/XMLSchema#string

P921

P932

3397789

http://www.w3.org/2001/XMLSchema#string