about
Variant base excision repair proteins: contributors to genomic instabilityTumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?Base excision repair and cancerAag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1( R )-β,γ-Fluoromethylene-dGTP-DNA Ternary Complex with DNA Polymerase βHalogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene AnaloguesHuman DNA Polymerase Mutations Allowing Efficient Abasic Site BypassStereospecific Formation of a Ternary Complex of (S)-α,β-Fluoromethylene-dATP with DNA Pol βStructural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase βUnfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s PathwayDNA Polymerases λ and β: The Double-Edged Swords of DNA RepairMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesBase excision repairDNA damage response genes and the development of cancer metastasisInter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair researchGastrointestinal hyperplasia with altered expression of DNA polymerase beta.Human cancers express mutator phenotypes: origin, consequences and targeting.DNA polymerase β contains a functional nuclear localization signal at its N-terminus.Irreversible inhibition of DNA polymerase β by small-molecule mimics of a DNA lesionRemote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantExpression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.Inhibition of short patch and long patch base excision repair by an oxidized abasic site.An Oxidized Abasic Lesion as an Intramolecular Source of DNA AdductsClinical significance of a point mutation in DNA polymerase beta (POLB) gene in gastric cancerDNA polymerases and human disease.Variation in base excision repair capacity.Long patch base excision repair compensates for DNA polymerase β inactivation by the C4'-oxidized abasic site.Repair of the major lesion resulting from C5'-oxidation of DNA.Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell linesY265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsImpact of reduced levels of APE1 transcripts on the survival of patients with urothelial carcinoma of the bladder.Human POLB gene is mutated in high percentage of colorectal tumors.Translesion DNA polymerases and cancerThe K167I variant of DNA polymerase β that is found in Esophageal Carcinoma patients impairs polymerase activity and BER.Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTPCellular fluid mechanics and mechanotransduction.Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaksTranscriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Is there a link between DNA polymerase beta and cancer?
@ast
Is there a link between DNA polymerase beta and cancer?
@en
Is there a link between DNA polymerase beta and cancer?
@nl
type
label
Is there a link between DNA polymerase beta and cancer?
@ast
Is there a link between DNA polymerase beta and cancer?
@en
Is there a link between DNA polymerase beta and cancer?
@nl
prefLabel
Is there a link between DNA polymerase beta and cancer?
@ast
Is there a link between DNA polymerase beta and cancer?
@en
Is there a link between DNA polymerase beta and cancer?
@nl
P2093
P356
P1433
P1476
Is there a link between DNA polymerase beta and cancer?
@en
P2093
Daniela Starcevic
Joann B Sweasy
Shibani Dalal
P304
P356
10.4161/CC.3.8.1062
P407
P577
2004-08-01T00:00:00Z