Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT
about
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and JunNa(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophyCrystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexesPhosphorylation of NFATc4 by p38 mitogen-activated protein kinasesIntegration of calcium and cyclic AMP signaling pathways by 14-3-3Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B)Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathwayStructure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal CoordinatesBalanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signalingHph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae.A calcineurin-dependent switch controls the trafficking function of α-arrestin Aly1/Art6.The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and DiseasesRequirement of two NFATc4 transactivation domains for CBP potentiationProtein kinase Czeta phosphorylates nuclear factor of activated T cells and regulates its transactivating activityNFAT proteins: key regulators of T-cell development and functionDominant negative Ras attenuates pathological ventricular remodeling in pressure overload cardiac hypertrophyNFATc1 balances quiescence and proliferation of skin stem cellsLipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factorsRequirement of transcription factor NFAT in developing atrial myocardiumA second calcineurin binding site on the NFAT regulatory domainTwo-site interaction of nuclear factor of activated T cells with activated calcineurinNFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db miceGenome-wide microarray analyses identify the protein C receptor as a novel calcineurin/nuclear factor of activated T cells-dependent gene in vascular smooth muscle cell phenotypic modulation.2-photon imaging of phagocyte-mediated T cell activation in the CNS.Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes.Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells.Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune diseaseNFAT proteins: emerging roles in cancer progression.Requirement for transcription factor NFAT in interleukin-2 expressionHigh-throughput screening of one-bead-one-compound libraries: identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction.The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identityEvolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4DCREB and the CRTC co-activators: sensors for hormonal and metabolic signalsStructure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction.Partners in transcription: NFAT and AP-1.Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules.The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel.The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity.Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein
P2860
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P2860
Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@ast
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@en
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@nl
type
label
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@ast
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@en
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@nl
prefLabel
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@ast
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@en
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@nl
P2093
P3181
P1433
P1476
Selective inhibition of NFAT a ...... ineurin targeting site of NFAT
@en
P2093
P304
P3181
P356
10.1016/S1097-2765(00)80063-5
P407
P577
1998-04-01T00:00:00Z