Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation
about
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase CRole of diacylglycerol kinase alpha in the attenuation of receptor signalingDiacylglycerol kinases in membrane traffickingDual regulation of diacylglycerol kinase (DGK)-θ: polybasic proteins promote activation by phospholipids and increase substrate affinityNuclear diacylglycerol kinase-theta is activated in response to alpha-thrombinMammalian diacylglycerol kinases, a family of lipid kinases with signaling functionsDiacylglycerol kinase zeta in hypothalamus interacts with long form leptin receptor. Relation to dietary fat and body weight regulationInterleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerolRegulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zetaActivation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitroModulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acidFatty acids inhibit growth-factor-induced diacylglycerol kinase alpha activation in vascular smooth-muscle cellsRegulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid productsDiacylglycerol kinase-alpha phosphorylation by Src on Y335 is required for activation, membrane recruitment and Hgf-induced cell motility.The diacylglycerol kinase α/atypical PKC/β1 integrin pathway in SDF-1α mammary carcinoma invasiveness.Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.Diacylglycerol Kinase Inhibition and Vascular FunctionThe expression of diacylglycerol kinase theta during the organogenesis of mouse embryos.Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.Substrate specificity of diacylglycerol kinase-epsilon and the phosphatidylinositol cycle.An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases.The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function.Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms.Src-mediated activation of alpha-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility.A domain with homology to neuronal calcium sensors is required for calcium-dependent activation of diacylglycerol kinase alpha.Receptor signaling in immune cell development and function.Nuclear Localization of Diacylglycerol Kinase Alpha in K562 Cells Is Involved in Cell Cycle Progression.Diacylglycerol kinase θ: regulation and stability.Diacylglycerol kinases are essential for hepatocyte growth factor-dependent proliferation and motility of Kaposi's sarcoma cells.Induction of heat shock protein gp96 by immune cytokines.Diacylglycerol kinase-dependent formation of phosphatidic acid molecular species during interleukin-2 activation in CTLL-2 T-lymphocytes.Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.Interleukin-2 stimulates a late increase in phosphatidic acid production in the absence of phospholipase D activation.Distinct expression and localization of diacylglycerol kinase isozymes in rat retina.Diacylglycerol kinase epsilon, but not zeta, selectively removes polyunsaturated diacylglycerol, inducing altered protein kinase C distribution in vivo.Dictyostelium discoideum has a single diacylglycerol kinase gene with similarity to mammalian theta isoforms.Hyper-reactivity of diacylglycerol kinase is involved in the dysfunction of aortic smooth muscle contractility in streptozotocin-induced diabetic rats.Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development.Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to high fat diet.
P2860
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P2860
Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation
description
1996 nî lūn-bûn
@nan
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@ast
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@en
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@nl
type
label
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@ast
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@en
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@nl
prefLabel
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@ast
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@en
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@nl
P2093
P2860
P356
P1476
Phosphatidic acid generation t ...... iated lymphocyte proliferation
@en
P2093
P2860
P304
P356
10.1074/JBC.271.17.10334
P407
P577
1996-04-26T00:00:00Z