Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle
about
Influence of Acute and Chronic Exercise on Glucose UptakeExercise and Regulation of Carbohydrate MetabolismRac1--a novel regulator of contraction-stimulated glucose uptake in skeletal muscleStretch-stimulated glucose transport in skeletal muscle is regulated by Rac1Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle.Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice.Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseasesRac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Musclep21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.Suppression of FoxO6 by lipopolysaccharide in aged rat liver.Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise.Putting Rac1 on the path to glucose uptake.Genome-wide landscape of DNA methylomes and their relationship with mRNA and miRNA transcriptomes in oxidative and glycolytic skeletal muscles.A proteolytic pathway that controls glucose uptake in fat and muscle.p21-Activated protein kinases and their emerging roles in glucose homeostasis.Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation.Rho GTPases in insulin-stimulated glucose uptake.Is contraction-stimulated glucose transport feedforward regulated by Ca2+?Molecular mechanisms for the regulation of insulin-stimulated glucose uptake by small guanosine triphosphatases in skeletal muscle and adipocytes.AMPK activation by prolonged stimulation with interleukin-1β contributes to the promotion of GLUT4 translocation in skeletal muscle cells.Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons.A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle.Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).Meta-fibrosis links positive energy balance and mitochondrial metabolism to insulin resistancePolymeric carrier-mediated intracellular delivery of phosphatidylinositol-3,4,5-trisphosphate to overcome insulin resistance.Pulmonary vascular effect of insulin in a rodent model of pulmonary arterial hypertension.Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out.The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells.Nitric oxide is required for the insulin sensitizing effects of contraction in mouse skeletal muscle.Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle.Rac1 is a novel regulator of exercise-induced glucose uptake.Differential effects of glucagon-like peptide-1 on microvascular recruitment and glucose metabolism in short- and long-term insulin resistance.The cell biology of systemic insulin function.When muscle doesn't 'Rac' it up, adipose tissue 'AKTs'.Group I Paks support muscle regeneration and counteract cancer-associated muscle atrophy.Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells.Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle.
P2860
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P2860
Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Rac1 signaling is required for ...... rine and human skeletal muscle
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Rac1 signaling is required for ...... rine and human skeletal muscle
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Rac1 signaling is required for ...... rine and human skeletal muscle
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Rac1 signaling is required for ...... rine and human skeletal muscle
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Rac1 signaling is required for ...... rine and human skeletal muscle
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Rac1 signaling is required for ...... rine and human skeletal muscle
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Rac1 signaling is required for ...... rine and human skeletal muscle
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Rac1 signaling is required for ...... rine and human skeletal muscle
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Rac1 signaling is required for ...... rine and human skeletal muscle
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P2860
P50
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P356
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Rac1 signaling is required for ...... rine and human skeletal muscle
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P2093
Kurt Højlund
P2860
P304
P3181
P356
10.2337/DB12-1148
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P50
P577
2013-06-01T00:00:00Z