Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease
about
Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expressionGene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphomaPhosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTENEarly-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's diseaseCalpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivoInteraction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spinesLoss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with agingAltered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients.Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in miceIn vivo, competitive blockade of N-methyl-D-aspartate receptors induces rapid changes in filamentous actin and drebrin A distributions within dendritic spines of adult rat cortex.Drebrin a content correlates with spine head size in the adult mouse cerebral cortexTransgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer's disease.Presenilin conditional double knockout mice exhibit decreases in drebrin a at hippocampal CA1 synapsesAltered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease.Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in ratsRETRACTED: Dose-dependent changes in neuroinflammatory and arachidonic acid cascade markers with synaptic marker loss in rat lipopolysaccharide infusion model of neuroinflammationDocosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse modelIs synaptic loss a unique hallmark of Alzheimer's disease?The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.Amyloid-β as a modulator of synaptic plasticityDrebrin contains a cryptic F-actin-bundling activity regulated by Cdk5 phosphorylation.Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease.Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence.Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic ratsRole of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brainHippocampal drebrin loss in mild cognitive impairment.Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1.Neuroinflammation and synaptic lossMetallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization.Targets of caspase-6 activity in human neurons and Alzheimer disease.Atomic force microscopy reveals drebrin induced remodeling of f-actin with subnanometer resolutionCaspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.Advances on the understanding of the origins of synaptic pathology in AD.Anesthetic Sevoflurane Causes Rho-Dependent Filopodial Shortening in Mouse NeuronsEffects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male SAMP8 mice.RETRACTED: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in the postmortem frontal cortex from schizophrenia patientsRole of drebrin A in dendritic spine plasticity and synaptic function: Implications in neurological disordersHydrogen sulfide attenuates neurodegeneration and neurovascular dysfunction induced by intracerebral-administered homocysteine in mice.Neurosteroids Involvement in the Epigenetic Control of Memory Formation and Storage.
P2860
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P2860
Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@ast
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@en
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@nl
type
label
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@ast
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@en
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@nl
prefLabel
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@ast
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@en
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@nl
P2093
P2860
P921
P3181
P356
P1476
Disappearance of actin-binding ...... ynapses in Alzheimer's disease
@en
P2093
P2860
P3181
P356
10.1002/JNR.490430111
P407
P577
1996-01-01T00:00:00Z