about
Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuityMechanisms of T cell organotropismReview of vedolizumab for the treatment of ulcerative colitisIntegrin-based therapeutics: biological basis, clinical use and new drugsLeukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory diseaseStable Coordination of the Inhibitory Ca2+ Ion at the Metal Ion-Dependent Adhesion Site in Integrin CD11b/CD18 by an Antibody-Derived Ligand Aspartate: Implications for Integrin Regulation and Structure-Based Drug DesignBiology and structure of leukocyte β 2 integrins and their role in inflammationMechanisms and consequences of neutrophil interaction with the endothelium.Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding.Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies.Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice.Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects.Neutrophil adhesion and chemotaxis depend on substrate mechanics.The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11bInflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression.Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial {alpha}5{beta}1 integrin.Lymphocyte modulation with FTY720 improves hemorrhagic shock survival in swinePurinergic regulation of neutrophil chemotaxis.Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent.Expression and targeting of lymphocyte function-associated antigen 1 (LFA-1) on white blood cells for treatment of allergic asthma.Absence of β2 integrins impairs regulatory T cells and exacerbates CD4+ T cell-dependent autoimmune carditisPlatelet-neutrophil interactions under thromboinflammatory conditionsRole of β1 integrin in tissue homing of neutrophils during sepsis.Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infectionsLymphocyte depletion in experimental hemorrhagic shock in Swine.Interfering with leukocyte integrin activation--a novel concept in the development of anti-inflammatory drugs.Pharmacology of AMG 181, a human anti-α4 β7 antibody that specifically alters trafficking of gut-homing T cells.Mechanisms of leukocyte migration across the blood-retina barrier.Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS).Mechanisms of neutrophil transendothelial migrationAgonist leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers.The ins and outs of leukocyte integrin signaling.Role of beta7 integrins in intestinal lymphocyte homing and retention.T-cell antigen receptor (TCR) transmembrane peptides: A new paradigm for the treatment of autoimmune diseases.Anti-adhesion molecule therapy for inflammatory bowel diseaseLeucocyte recruitment in inflammation and novel endogenous negative regulators thereof.Inhibition of selective adhesion molecules in treatment of inflammatory bowel disease.New therapeutic approaches for protecting hematopoietic stem cells in aplastic anemia.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Targeting leukocyte integrins in human diseases
@ast
Targeting leukocyte integrins in human diseases
@en
Targeting leukocyte integrins in human diseases
@nl
type
label
Targeting leukocyte integrins in human diseases
@ast
Targeting leukocyte integrins in human diseases
@en
Targeting leukocyte integrins in human diseases
@nl
prefLabel
Targeting leukocyte integrins in human diseases
@ast
Targeting leukocyte integrins in human diseases
@en
Targeting leukocyte integrins in human diseases
@nl
P2860
P3181
P356
P1476
Targeting leukocyte integrins in human diseases
@en
P2093
John M Harlan
Karyn Yonekawa
P2860
P304
P3181
P356
10.1189/JLB.0804460
P407
P577
2005-02-01T00:00:00Z