Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function
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Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewCardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy PhenotypeProtein Structure-Function Relationship at Work: Learning from Myopathy Mutations of the Slow Skeletal Muscle Isoform of Troponin TPhosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin TThe heart-specific NH2-terminal extension regulates the molecular conformation and function of cardiac troponin IToad heart utilizes exclusively slow skeletal muscle troponin T: an evolutionary adaptation with potential functional benefitsDeficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigueMuscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegansSerological screening of the Schistosoma mansoni adult worm proteomeTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function.Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle.Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammals.FRET study of the structural and kinetic effects of PKC phosphomimetic cardiac troponin T mutants on thin filament regulation.Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathyIn situ time-resolved FRET reveals effects of sarcomere length on cardiac thin-filament activation.A dominantly negative mutation in cardiac troponin I at the interface with troponin T causes early remodeling in ventricular cardiomyocytesCategorization of 77 dystrophin exons into 5 groups by a decision tree using indexes of splicing regulatory factors as decision markers.Top-down mass spectrometry of cardiac myofilament proteins in health and disease.Abnormal splicing in the N-terminal variable region of cardiac troponin T impairs systolic function of the heart with preserved Frank-Starling compensationHuman slow troponin T (TNNT1) pre-mRNA alternative splicing is an indicator of skeletal muscle response to resistance exercise in older adults.NH2-terminal truncations of cardiac troponin I and cardiac troponin T produce distinct effects on contractility and calcium homeostasis in adult cardiomyocytesStructure of the NH2-terminal variable region of cardiac troponin T determines its sensitivity to restrictive cleavage in pathophysiological adaptationProteomics of muscle chronological ageing in post-menopausal womenDissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry.A nanostructured piezoelectric immunosensor for detection of human cardiac troponin TOxidative proteome alterations during skeletal muscle ageingEngineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.Protein Profiles for Muscle Development and Intramuscular Fat Accumulation at Different Post-Hatching Ages in Chickens.Transcriptome analysis reveals that constant heat stress modifies the metabolism and structure of the porcine longissimus dorsi skeletal muscle.Chronic coexistence of two troponin T isoforms in adult transgenic mouse cardiomyocytes decreased contractile kinetics and caused dilatative remodelingThe N-terminal extension of cardiac troponin T stabilizes the blocked state of cardiac thin filamentMolecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT.Troponin T nuclear localization and its role in aging skeletal muscleCalpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary miceDiscontinuous thoracic venous cardiomyocytes and heart exhibit synchronized developmental switch of troponin isoforms.Divergent effects of α- and β-myosin heavy chain isoforms on the N terminus of rat cardiac troponin T.Deer Antler Extract Improves Fatigue Effect through Altering the Expression of Genes Related to Muscle Strength in Skeletal Muscle of Mice.TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.Quantitative proteome profiling of dystrophic dog skeletal muscle reveals a stabilized muscular architecture and protection against oxidative stress after systemic delivery of MuStem cells.
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P2860
Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function
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2011 nî lūn-bûn
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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2011 թվականի հունվարին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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Troponin T isoforms and posttr ...... ution, regulation and function
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Troponin T isoforms and posttr ...... ution, regulation and function
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Troponin T isoforms and posttr ...... ution, regulation and function
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Troponin T isoforms and posttr ...... ution, regulation and function
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Troponin T isoforms and posttr ...... ution, regulation and function
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Troponin T isoforms and posttr ...... ution, regulation and function
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Troponin T isoforms and posttr ...... ution, regulation and function
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Troponin T isoforms and posttr ...... ution, regulation and function
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Troponin T isoforms and posttr ...... ution, regulation and function
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P2860
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Troponin T isoforms and posttr ...... ution, regulation and function
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P2860
P304
P3181
P356
10.1016/J.ABB.2010.10.013
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P577
2011-01-15T00:00:00Z