Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity
about
Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse ChemotherapeuticsDeoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteriaRemoval of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved PharmacokineticsDerivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.Molecular evidence of Zn chelation of the procaspase activating compound B-PAC-1 in B cell lymphoma.The Combination of Vemurafenib and Procaspase-3 Activation Is Synergistic in Mutant BRAF Melanomas.Green synthesis of bacterial mediated anti-proliferative gold nanoparticles: inducing mitotic arrest (G2/M phase) and apoptosis (intrinsic pathway).Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients.Substituent effects on stereoselectivity of dihalocarbene reactions with cyclohexadiene and on the reactivity of bis-dihalocyclopropanes in electrophilic nitrations en route to pyrimidine N-oxides.
P2860
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P2860
Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-hans
2014年学术文章
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2014年学术文章
@zh-sg
2014年學術文章
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name
Dual small-molecule targeting ...... vation and anticancer activity
@ast
Dual small-molecule targeting ...... vation and anticancer activity
@en
Dual small-molecule targeting ...... vation and anticancer activity
@nl
type
label
Dual small-molecule targeting ...... vation and anticancer activity
@ast
Dual small-molecule targeting ...... vation and anticancer activity
@en
Dual small-molecule targeting ...... vation and anticancer activity
@nl
prefLabel
Dual small-molecule targeting ...... vation and anticancer activity
@ast
Dual small-molecule targeting ...... vation and anticancer activity
@en
Dual small-molecule targeting ...... vation and anticancer activity
@nl
P2093
P2860
P3181
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P1476
Dual small-molecule targeting ...... vation and anticancer activity
@en
P2093
Levent Dirikolu
Paul J Hergenrother
Rachel C Botham
Timothy M Fan
P2860
P304
P3181
P356
10.1021/JA4124303
P407
P50
P577
2014-01-16T00:00:00Z