Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones
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Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90Heat shock protein 90: role in enterovirus 71 entry and assembly and potential target for therapyIdentification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbitalPhase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignanciesHSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts.The cellular chaperone heat shock protein 90 facilitates Flock House virus RNA replication in Drosophila cells.Hsp90β inhibition modulates nitric oxide production and nitric oxide-induced apoptosis in human chondrocytesEffect of inhibition of the ubiquitin-proteasome system and Hsp90 on growth and survival of rhabdomyosarcoma cells in vitro.A small heat shock protein is essential for thermotolerance and intracellular survival of Leishmania donovani.HSP90 as a new therapeutic target for cancer therapy: the story unfolds.Cellular stress rather than stage of the cell cycle enhances the replication and plating efficiencies of herpes simplex virus type 1 ICP0- virusesIdentification and characterisation of a novel heat shock protein 90 inhibitor ONO4140.A functional heat shock protein 90 chaperone is essential for efficient flock house virus RNA polymerase synthesis in Drosophila cells.Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond.Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro.Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-alpha regulation.Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthaseA unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.Heat shock protein 90-α mediates aldo-keto reductase 1B10 (AKR1B10) protein secretion through secretory lysosomes.CD24 promoted cancer cell angiogenesis via Hsp90-mediated STAT3/VEGF signaling pathway in colorectal cancer.Unfolding the promise of translational targeting in neurodegenerative disease.Heat shock protein 90β in the Vero cell membrane binds Japanese encephalitis virus.The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer.Geldanamycin-induced PCNA degradation in isolated Hsp90 complex from cancer cells.Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion.Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementationGeldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo.Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL--Inhibition of P-glycoprotein function by 17-AAG.
P2860
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P2860
Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones
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2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Geldanamycin: the prototype of ...... family of molecular chaperones
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Geldanamycin: the prototype of ...... family of molecular chaperones
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Geldanamycin: the prototype of ...... family of molecular chaperones
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Geldanamycin: the prototype of ...... family of molecular chaperones
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Geldanamycin: the prototype of ...... family of molecular chaperones
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Geldanamycin: the prototype of ...... family of molecular chaperones
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Geldanamycin: the prototype of ...... family of molecular chaperones
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Geldanamycin: the prototype of ...... family of molecular chaperones
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Geldanamycin: the prototype of ...... family of molecular chaperones
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P2093
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Geldanamycin: the prototype of ...... family of molecular chaperones
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P2093
P2860
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10.1379/1466-1268(2001)006<0105:GTPOAC>2.0.CO;2
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P577
2001-04-01T00:00:00Z