Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis - sprookjes - yvandenbroek - TriplyDB

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

http://www.wikidata.org/entity/Q28386212

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Aging of hematopoietic stem cells: DNA damage and mutations?Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance Molecular Testing in Myelodysplastic Syndromes for the Practicing Oncologist: Will the Progress Fulfill the Promise?Genomic Classification and Prognosis in Acute Myeloid Leukemia.Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes Accumulation of DNA damage in the aged hematopoietic stem cell compartment The ageing genome, clonal mosaicism and chronic disease.Recent advances in the understanding of myelodysplastic syndromes with ring sideroblasts.How do messenger RNA splicing alterations drive myelodysplasia?Molecular features of early onset adult myelodysplastic syndrome ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study.Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.HSC Aging and Senescent Immune Remodeling.Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms.Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes.Acute myeloid leukemia in the era of precision medicine: recent advances in diagnostic classification and risk stratification.Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.Cell cycle of primitive hematopoietic progenitors decelerated in senescent mice is reactively accelerated after 2-Gy whole-body irradiation Age-related mutations and chronic myelomonocytic leukemia.Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms.Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD).Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes.Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.Isocitrate dehydrogenase mutations in myeloid malignancies.Preleukemia: one name, many meanings.Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts.Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study.Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.

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Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

http://www.wikidata.org/entity/Q28386212

description

2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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type

label

Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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prefLabel

Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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J.CELREP.2015.02.005

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Leukemia-associated somatic mu ...... age-related clonal hemopoiesis

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Carolyn S Grove

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Charles Crawley

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Clare Hodkinson

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Duncan R Forsyth

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Hannes Ponstingl

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Jenny Craig

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Mike A Scott

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Naomi Park

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Detectable clonal mosaicism and its relationship to aging and cancer

Epigenetic differences arise during the lifetime of monozygotic twins

The Sequence Alignment/Map format and SAMtools

The clonal evolution of tumor cell populations

Detectable clonal mosaicism from birth to old age and its relationship to cancer

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Age-related clonal hematopoiesis associated with adverse outcomes

Age-related mutations associated with clonal hematopoietic expansion and malignancies

Clonal evolution in cancer

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1239-45

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10.1016/J.CELREP.2015.02.005

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8

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Eleftheria Zeggini

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Michael Andrew Quail

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2015-03-03T00:00:00Z

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273156668

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25732814

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