Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression - sprookjes - yvandenbroek - TriplyDB

Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression

Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression

http://www.wikidata.org/entity/Q28392546

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Indirubin-3'-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis Regulation of Nrf2-an update Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy Oncogene PKCε controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2 The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?Cytoprotection "gone astray": Nrf2 and its role in cancer Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine NRF2-regulation in brain health and disease: implication of cerebral inflammation Oxidative status interactome map: towards novel approaches in experiment planning, data analysis, diagnostics and therapy.Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation.The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells.Increased antioxidant defense mechanism in human adventitia-derived progenitor cells is associated with therapeutic benefit in ischemia Therapeutic targeting of GSK3β enhances the Nrf2 antioxidant response and confers hepatic cytoprotection in hepatitis C.A Bovine Lymphosarcoma Cell Line Infected with Theileria annulata Exhibits an Irreversible Reconfiguration of Host Cell Gene Expression.A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer.Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.Glutathione synthesis and its role in redox signaling.Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways.Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy.GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion.Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.The GSK-3β/Fyn/Nrf2 pathway in fibroblasts and wounds of type 2 diabetes: On the road to an evidence-based therapy of non-healing wounds.Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells.Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1B.Phytochemical regulation of Fyn and AMPK signaling circuitry.The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases.Temporal and spatial distribution of Nrf2 in rat brain following stroke: quantification of nuclear to cytoplasmic Nrf2 content using a novel immunohistochemical technique.Genetic and Pharmacologic Targeting of Glycogen Synthase Kinase 3β Reinforces the Nrf2 Antioxidant Defense against Podocytopathy.Nuclear factor (erythroid-derived 2)-like 2, the brake in oxidative stress that nicotinamide adenine dinucleotide phosphate-oxidase-4 needs to protect the heart.The Role of Nrf2 in Cardiovascular Function and Disease.

P2860

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P2860

Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression

http://www.wikidata.org/entity/Q28392546

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

name

Src subfamily kinases regulate ...... cytoprotective gene expression

@ast

Src subfamily kinases regulate ...... cytoprotective gene expression

@en

Src subfamily kinases regulate ...... cytoprotective gene expression

@nl

type

label

Src subfamily kinases regulate ...... cytoprotective gene expression

@ast

Src subfamily kinases regulate ...... cytoprotective gene expression

@en

Src subfamily kinases regulate ...... cytoprotective gene expression

@nl

prefLabel

Src subfamily kinases regulate ...... cytoprotective gene expression

@ast

Src subfamily kinases regulate ...... cytoprotective gene expression

@en

Src subfamily kinases regulate ...... cytoprotective gene expression

@nl

P1433

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JBC.M111.255042

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Journal of Biological Chemistry

P1476

Src subfamily kinases regulate ...... cytoprotective gene expression

@en

P2093

Abhinav K Jain

http://www.w3.org/2001/XMLSchema#string

Anil K Jaiswal

http://www.w3.org/2001/XMLSchema#string

Phillip M Shelton

http://www.w3.org/2001/XMLSchema#string

Suryakant K Niture

http://www.w3.org/2001/XMLSchema#string

P2860

Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice

The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration

Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response e

Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration

An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

Nrf2 signaling and cell survival

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

Nrf2:INrf2 (Keap1) signaling in oxidative stress

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

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28821-32

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scholarly article

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3070931

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10.1074/JBC.M111.255042

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33

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286

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21690096

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3190690

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