A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
about
DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsMolecular mechanisms in multiple myeloma drug resistanceThe 26S proteasome is a multifaceted target for anti-cancer therapiesTargeting the ubiquitin pathway for cancer treatmentTargeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cellsDisassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compoundsAllosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20JNK-NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stressSynthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15Deubiquitinases (DUBs) and DUB inhibitors: a patent reviewUbiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junctionDeubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability.Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibitionStructure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targetsOverexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.The ubiquitin-proteasome system: opportunities for therapeutic intervention in solid tumorsClinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growthElevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.CSNK1α1 mediates malignant plasma cell survival.Inhibitory effect of b-AP15 on the 20S proteasomeProteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cellsTherapeutic landscape of carfilzomib and other modulators of the ubiquitin-proteasome pathway.Deubiquitinases in cancer.Discovery of an Inhibitor of the Proteasome Subunit Rpn11.UCHL1 is a biomarker of aggressive multiple myeloma required for disease progressionTwo clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo.The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle ProgressionThe proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cellsUSP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosisUSP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment.The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeuticsCDDO-Me reveals USP7 as a novel target in ovarian cancer cells.Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor.Understanding biology to tackle the disease: Multiple myeloma from bench to bedside, and back.SCF ubiquitin ligase-targeted therapies.DUBs, the regulation of cell identity and disease.
P2860
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P2860
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
description
2014 nî lūn-bûn
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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A novel small molecule inhibit ...... vercomes bortezomib resistance
@ast
A novel small molecule inhibit ...... vercomes bortezomib resistance
@en
A novel small molecule inhibit ...... vercomes bortezomib resistance
@nl
type
label
A novel small molecule inhibit ...... vercomes bortezomib resistance
@ast
A novel small molecule inhibit ...... vercomes bortezomib resistance
@en
A novel small molecule inhibit ...... vercomes bortezomib resistance
@nl
prefLabel
A novel small molecule inhibit ...... vercomes bortezomib resistance
@ast
A novel small molecule inhibit ...... vercomes bortezomib resistance
@en
A novel small molecule inhibit ...... vercomes bortezomib resistance
@nl
P2093
P2860
P50
P3181
P1433
P1476
A novel small molecule inhibit ...... vercomes bortezomib resistance
@en
P2093
Arghya Ray
Dharminder Chauhan
Ruben D Carrasco
Stig Linder
Yu-Tzu Tai
P2860
P304
P3181
P356
10.1182/BLOOD-2013-05-500033
P407
P577
2013-12-06T00:00:00Z