Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
about
Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localizationSmall molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infectionEbola virus entry requires the cholesterol transporter Niemann-Pick C1Endosome maturationRole of SNX16 in the dynamics of tubulo-cisternal membrane domains of late endosomesAn isoprenylation and palmitoylation motif promotes intraluminal vesicle delivery of proteins in cells from distant speciesCathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasmThe C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathwayMultiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infectionA new player in the puzzle of filovirus entry.Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.In vitro intracellular trafficking of virulence antigen during infection by Yersinia pestis.Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders.The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry.Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cellsCholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation.Secondary lipid accumulation in lysosomal disease.The dark sides of capillary morphogenesis gene 2.Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo.Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis.Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane FusionIdentification of agents effective against multiple toxins and viruses by host-oriented cell targeting.Rab GTPases implicated in inherited and acquired disorders.The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteinsLeishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host.In vitro budding of intralumenal vesicles into late endosomes is regulated by Alix and Tsg101Origins of intestinal ABCA1-mediated HDL-cholesterol.Identification of an intracellular site of prion conversion.Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning.Drug-drug interactions involving lysosomes: mechanisms and potential clinical implications.Ceramide function in the brain: when a slight tilt is enough.The Intracellular Cholesterol Transport Inhibitor U18666A Inhibits the Exosome-Dependent Release of Mature Hepatitis C Virus.Lipids, lysosomes, and autophagy.The microtubule motor protein KIF13A is involved in intracellular trafficking of the Lassa virus matrix protein Z.Impaired dynamics of the late endosome/lysosome compartment in human Niemann-Pick type C skin fibroblasts carrying mutation in NPC1 gene.Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells.First-Generation Antipsychotic Haloperidol Alters the Functionality of the Late Endosomal/Lysosomal Compartment in Vitro
P2860
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P2860
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@ast
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@en
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@nl
type
label
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@ast
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@en
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@nl
prefLabel
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@ast
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@en
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@nl
P2093
P2860
P1433
P1476
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking
@en
P2093
Charles Ferguson
F Gisou van der Goot
Isabelle Le Blanc
Jean Gruenberg
Komla Sobo
Pierre-Philippe Luyet
P2860
P356
10.1371/JOURNAL.PONE.0000851
P407
P577
2007-09-05T00:00:00Z