Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons - sprookjes - yvandenbroek - TriplyDB

Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons

Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons

http://www.wikidata.org/entity/Q28473591

about

p38 MAPK and PI3K/AKT Signalling Cascades inParkinson's Disease Conservation of oxidative protein stabilization in an insect homologue of parkinsonism-associated protein DJ-1 GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease The Protective Effect of Minocycline in a Paraquat-Induced Parkinson's Disease Model in Drosophila is Modified in Altered Genetic Backgrounds.Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies.Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration Receptor tyrosine kinases in Drosophila development.Neuroprotective function of DJ-1 in Parkinson's disease.Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants.Parkinson's disease mouse models in translational research.Trophic neuron-glia interactions and cell number adjustments in the fruit fly.The role of DJ-1 in the oxidative stress cell death cascade after stroke Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model.DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA.Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction.Oxygen-glucose-deprived rat primary neural cells exhibit DJ-1 translocation into healthy mitochondria: a potent stroke therapeutic target.The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system.DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway.Crosstalk of parkin and Ret in dopaminergic neurons.DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease.Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival.Regulation of Signal Transduction by DJ-1.Overexpression of DJ-1/PARK7, the Parkinson's disease-related protein, improves mitochondrial function via Akt phosphorylation on threonine 308 in dopaminergic neuron-like cells.Aging of the dopaminergic system and motor behavior in mice intoxicated with the parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area.

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P2860

Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons

http://www.wikidata.org/entity/Q28473591

description

2010 nî lūn-bûn

@nan

2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Pro-survival role for Parkinso ...... impaired dopaminergic neurons

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Pro-survival role for Parkinso ...... impaired dopaminergic neurons

@en

Pro-survival role for Parkinso ...... impaired dopaminergic neurons

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type

label

Pro-survival role for Parkinso ...... impaired dopaminergic neurons

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Pro-survival role for Parkinso ...... impaired dopaminergic neurons

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Pro-survival role for Parkinso ...... impaired dopaminergic neurons

@nl

prefLabel

Pro-survival role for Parkinso ...... impaired dopaminergic neurons

@ast

Pro-survival role for Parkinso ...... impaired dopaminergic neurons

@en

Pro-survival role for Parkinso ...... impaired dopaminergic neurons

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Pro-survival role for Parkinso ...... impaired dopaminergic neurons

@en

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Edgar R Kramer

http://www.w3.org/2001/XMLSchema#string

Liviu Aron

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Pontus Klein

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Rüdiger Klein

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Thu-Trang Pham

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Wolfgang Wurst

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P2860

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

DJ-1 has a role in antioxidative stress to prevent cell death

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions

Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice

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10.1371/JOURNAL.PBIO.1000349

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20386724

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P921

Parkinson's disease

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2850379

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