Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening
about
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activatorCrystal and Solution Structures of a Prokaryotic M16B Peptidase: an Open and Shut CaseDesigned Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of InsulinAnion Activation Site of Insulin-degrading EnzymeImidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysisStructure based discovery of small molecules to regulate the activity of human insulin degrading enzymePeptidomics approach to elucidate the proteolytic regulation of bioactive peptides.Cell-permeable, small-molecule activators of the insulin-degrading enzyme.Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanismStructure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway.Current therapeutic targets for the treatment of Alzheimer's disease.Proteolytic degradation of amyloid β-protein.Metallostasis and amyloid β-degrading enzymes.Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes MellitusPotential efficacy of Lactobacillus casei IBRC_M10711 on expression and activity of insulin degrading enzyme but not insulin degradation.New Insights into Epigenetic and Pharmacological Regulation of Amyloid-Degrading Enzymes.Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease.Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-β Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer's Disease.Stimulating the Activity of Amyloid-Beta Degrading Enzymes: A Novel Approach for the Therapeutic Manipulation of Amyloid-Beta Levels.Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display.Multiple functions of insulin-degrading enzyme: a metabolic crosslight?Inhibition of Insulin Degrading Enzyme and Insulin Degradation by UV-Killed Lactobacillus acidophilus.
P2860
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P2860
Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Small-molecule activators of i ...... -throughput compound screening
@ast
Small-molecule activators of i ...... -throughput compound screening
@en
Small-molecule activators of i ...... -throughput compound screening
@nl
type
label
Small-molecule activators of i ...... -throughput compound screening
@ast
Small-molecule activators of i ...... -throughput compound screening
@en
Small-molecule activators of i ...... -throughput compound screening
@nl
prefLabel
Small-molecule activators of i ...... -throughput compound screening
@ast
Small-molecule activators of i ...... -throughput compound screening
@en
Small-molecule activators of i ...... -throughput compound screening
@nl
P2093
P2860
P1433
P1476
Small-molecule activators of i ...... -throughput compound screening
@en
P2093
Christelle Cabrol
Christopher Dinolfo
Dennis J Selkoe
Gregory D Cuny
Lael Reinstatler
Malcolm A Leissring
Malwina A Huzarska
Maria C Rodriguez
P2860
P356
10.1371/JOURNAL.PONE.0005274
P407
P577
2009-01-01T00:00:00Z