Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery
about
Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosisFiloviral immune evasion mechanismsIntracellular events and cell fate in filovirus infectionDRBP76 associates with Ebola virus VP35 and suppresses viral polymerase functionIRF7: activation, regulation, modification and functionMutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcomeThe Role of Cytokines and Chemokines in Filovirus InfectionMultifunctional roles of leader protein of foot-and-mouth disease viruses in suppressing host antiviral responsesFiloviruses: One of These Things is (not) Like the OtherEbolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppressionStructural basis for dsRNA recognition and interferon antagonism by Ebola VP35Zika (PRVABC59) Infection Is Associated with T cell Infiltration and Neurodegeneration in CNS of Immunocompetent Neonatal C57Bl/6 MiceKaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivationA Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola VirusThe small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activationEbolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling.Asunaprevir Evokes Hepatocytes Innate Immunity to Restrict the Replication of Hepatitis C and Dengue Virus.Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific.The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivationDeubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye.Viral manipulation of the cellular sumoylation machinery.Murine gamma herpesvirus 68 hijacks MAVS and IKKβ to abrogate NFκB activation and antiviral cytokine production.Viral hijacking of the host ubiquitin system to evade interferon responses.Interplay between innate immunity and negative-strand RNA viruses: towards a rational modelAntagonism of type I interferon responses by new world hantavirusesHow Ebola virus counters the interferon system.Dengue virus serotype 2 blocks extracellular signal-regulated kinase and nuclear factor-κB activation to downregulate cytokine production.Camouflage and misdirection: the full-on assault of ebola virus diseaseMolecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.An upstream open reading frame modulates ebola virus polymerase translation and virus replication.Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses.Ebolavirus VP35 is a multifunctional virulence factor.SUMO and KSHV ReplicationIdentification of sumoylated proteins in the silkworm Bombyx mori.Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies.A simian hemorrhagic fever virus isolate from persistently infected baboons efficiently induces hemorrhagic fever disease in Japanese macaquesHPV E6 proteins target Ubc9, the SUMO conjugating enzyme.Sumoylation inhibits alpha-synuclein aggregation and toxicity.
P2860
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P2860
Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@ast
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@en
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@nl
type
label
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@ast
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@en
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@nl
prefLabel
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@ast
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@en
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@nl
P2093
P2860
P3181
P1433
P1476
Ebola Zaire virus blocks type ...... st SUMO modification machinery
@en
P2093
Keiko Ozato
Mayumi Matsuoka
Steven B Bradfute
Steven Jones
Toru Kubota
Tsung-Hsien Chang
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1000493
P407
P577
2009-06-01T00:00:00Z