A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
about
Adipogenesis is under surveillance of Hsp90 and the high molecular weight Immunophilin FKBP51Steroid Receptor-Associated Immunophilins: A Gateway to Steroid SignallingMolecular and genetic basis of depressionSelective inhibitors of the FK506-binding protein 51 by induced fitThe emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's diseaseAssociation of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humansAllele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactionsAge-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational ImplicationsAccelerated neurodegeneration through chaperone-mediated oligomerization of tau.The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans.Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiationNeuroendocrinology of a Male-Specific Pattern for Depression Linked to Alcohol Use Disorder and Suicidal Behavior.Animal models of stress vulnerability and resilience in translational research.The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance.Targeting Hsp90 and its co-chaperones to treat Alzheimer's diseaseFK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change.FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications.Pharmacogenetics and Imaging-Pharmacogenetics of Antidepressant Response: Towards Translational Strategies.Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice.Neurobiological mechanisms of stress resilience and implications for the aged population.MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation.Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes.The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signalingIncreased glyoxalase-1 levels in Fkbp5 knockout mice caused by glyoxalase-1 gene duplication.Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51.Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding.Molecular dynamics simulation, binding free energy calculation and unbinding pathway analysis on selectivity difference between FKBP51 and FKBP52: Insight into the molecular mechanism of isoform selectivity.Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine.The prospect of FKBP51 as a drug target.Hsp90 and FKBP51: complex regulators of psychiatric diseases.Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD
P2860
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P2860
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51
@nl
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
@ast
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
@en
type
label
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51
@nl
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
@ast
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
@en
prefLabel
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51
@nl
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
@ast
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
@en
P2093
P2860
P3181
P1433
P1476
A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.
@en
P2093
Amelia G Johnson
Chad A Dickey
Edwin J Weeber
Gabriel de Erausquin
John C O'Leary
Joyce Cheung-Flynn
Laura J Blair
Marc B Cox
Melinda Peters
Sarah Brady
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0024840
P407
P577
2011-09-15T00:00:00Z