A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A
about
Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutationsHepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5ALymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesisEfficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cellsHepatitis C virus RNA replication depends on specific cis- and trans-acting activities of viral nonstructural proteinsA screen for novel hepatitis C virus RdRp inhibitor identifies a broad-spectrum antiviral compoundViral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.Identification and functional characterization of the nascent RNA contacting residues of the hepatitis C virus RNA-dependent RNA polymerase.The hepatitis C virus core protein can modulate RNA-dependent RNA synthesis by the 2a polymerase.Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formationA single nucleotide polymorphism associated with hepatitis C virus infections located in the distal region of the IL28B promoter influences NF-κB-mediated gene transcriptionVPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assayCyclophilin inhibitors: an emerging class of therapeutics for the treatment of chronic hepatitis C infectionNon-encapsidation activities of the capsid proteins of positive-strand RNA viruses.NOD1 Participates in the Innate Immune Response Triggered by Hepatitis C Virus PolymeraseThe juxtamembrane sequence of the Hepatitis C virus polymerase can affect RNA synthesis and inhibition by allosteric polymerase inhibitors.The classic swine fever virus (CSFV) core protein can enhance de novo-initiated RNA synthesis by the CSFV polymerase NS5B.Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations.RNA synthesis by the brome mosaic virus RNA-dependent RNA polymerase in human cells reveals requirements for de novo initiation and protein-protein interaction.NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.Hepatitis C virus NS5B polymerase primes innate immune signaling.A Crystal Structure of Classical Swine Fever Virus NS5B Reveals a Novel N-terminal Domain.
P2860
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P2860
A cell-based assay for RNA synthesis by the HCV polymerase reveals new insights on mechanism of polymerase inhibitors and modulation by NS5A
description
2011 nî lūn-bûn
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2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@ast
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@en
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@nl
type
label
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@ast
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@en
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@nl
prefLabel
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@ast
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@en
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@nl
P2093
P2860
P1433
P1476
A cell-based assay for RNA syn ...... ibitors and modulation by NS5A
@en
P2093
C Cheng Kao
C T Ranjith-Kumar
Kanchan Bhardwaj
Yahong Wen
P2860
P304
P356
10.1371/JOURNAL.PONE.0022575
P407
P577
2011-01-01T00:00:00Z