4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo
about
The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosisStructure, Biochemistry, and Inhibition of Essential 4′-Phosphopantetheinyl Transferases from Two Species of MycobacteriaTrehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in MiceThe phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for lifeA Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.Regulated Expression Systems for Mycobacteria and Their Applications4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.Paenibacillus polymyxa A26 Sfp-type PPTase inactivation limits bacterial antagonism against Fusarium graminearum but not of F. culmorum in kernel assay.Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategyGenetic Approaches to Facilitate Antibacterial Drug Development.A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid deathBiosynthesis of mycobacterial lipids by polyketide synthases and beyond.Newer patents in antimycobacterial therapy.Survival proteomes: the emerging proteotype of antimicrobial resistance.Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors.Sfp-type PPTase inactivation promotes bacterial biofilm formation and ability to enhance wheat drought tolerance.Global adaptation to a lipid environment triggers the dormancy-related phenotype of Mycobacterium tuberculosis.Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.Insights from the docking and molecular dynamics simulation of the Phosphopantetheinyl transferase (PptT) structural model from Mycobacterium tuberculosis.Mass spectral determination of phosphopantetheinylation specificity for carrier proteins in Mycobacterium tuberculosisA Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level.The Emergence of the First Cells
P2860
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P2860
4'-Phosphopantetheinyl transferase PptT, a new drug target required for Mycobacterium tuberculosis growth and persistence in vivo
description
2012 nî lūn-bûn
@nan
2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@ast
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@en
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@nl
type
label
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@ast
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@en
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@nl
prefLabel
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@ast
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@en
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@nl
P2093
P2860
P3181
P1433
P1476
4'-Phosphopantetheinyl transfe ...... growth and persistence in vivo
@en
P2093
Aurélie Ray
Christian Chalut
Christophe Guilhot
Cécile Leblanc
Guillaume Tabouret
Lionel Mourey
Sophie Burbaud
Stéphanie Cabantous
Thomas Prudhomme
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1003097
P407
P577
2012-12-01T00:00:00Z