Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference

Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference

Item
http://www.wikidata.org/entity/Q28486133
Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrateThe microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay.Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignanciesDi-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).Application of fluorescent dye substrates for functional characterization of ABC multidrug transporters at a single cell level.A Flow Cytometry Method for Rapidly Assessing Mycobacterium tuberculosis Responses to Antibiotics with Different Modes of ActionHuman ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1Nature and uses of fluorescent dyes for drug transporter studies.A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image AnalysisTPGS/Phospholipids Mixed Micelles for Delivery of Icariside II to Multidrug-Resistant Breast Cancer.Phenotypic drug profiling in droplet microfluidics for better targeting of drug-resistant tumors.Cell-free microfluidic determination of P-glycoprotein interactions with substrates and inhibitors.The synergistic role of ATP-dependent drug efflux pump and focal adhesion signaling pathways in vinorelbine resistance in lung cancer.The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations.Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery.
P2860

Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference

Item
http://www.wikidata.org/entity/Q28486133
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Screening compounds with a nov ...... tidrug resistance interference
@ast
Screening compounds with a nov ...... tidrug resistance interference
@en
Screening compounds with a nov ...... tidrug resistance interference
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type
label
Screening compounds with a nov ...... tidrug resistance interference
@ast
Screening compounds with a nov ...... tidrug resistance interference
@en
Screening compounds with a nov ...... tidrug resistance interference
@nl
prefLabel
Screening compounds with a nov ...... tidrug resistance interference
@ast
Screening compounds with a nov ...... tidrug resistance interference
@en
Screening compounds with a nov ...... tidrug resistance interference
@nl
P1433
P1476
P2093
P2860
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Screening compounds with a nov ...... tidrug resistance interference
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P2093
P2860
P304
P31
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10.1371/JOURNAL.PONE.0060334
P407
P433
P478
P577
P5875
P698
P921
P932