The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus
about
Bacterial ProteasomesThe pup-proteasome system of Mycobacterium tuberculosisProkaryotic ubiquitin-like protein modificationStructural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasomeBinding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradationStructures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathwayBacterial Proteasomes: Mechanistic and Functional InsightsA novel copper-responsive regulon in Mycobacterium tuberculosis"Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substratesDop functions as a depupylase in the prokaryotic ubiquitin-like modification pathwayBacterial proteasome activator bpa (rv3780) is a novel ring-shaped interactor of the mycobacterial proteasomeDisordered proteinaceous machinesProkaryotic ubiquitin-like protein remains intrinsically disordered when covalently attached to proteasomal target proteinsRational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.Survival of mycobacteria depends on proteasome-mediated amino acid recycling under nutrient limitationThe pupylation pathway and its role in mycobacteria.Mycobacterial ubiquitin-like protein ligase PafA follows a two-step reaction pathway with a phosphorylated pup intermediate.Fate of pup inside the Mycobacterium proteasome studied by in-cell NMR.Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coliPupylated proteins in Corynebacterium glutamicum revealed by MudPIT analysis.An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis.Uncovering ubiquitin and ubiquitin-like signaling networks.Proteasomes and protein conjugation across domains of life.Activity of the mycobacterial proteasomal ATPase Mpa is reversibly regulated by pupylation.The Mechanism of Mycobacterium smegmatis PafA Self-PupylationMycobacterium tuberculosis prokaryotic ubiquitin-like protein-deconjugating enzyme is an unusual aspartate amidase.The archaeal proteasome is regulated by a network of AAA ATPasesDesign principles of a universal protein degradation machine.Allosteric transitions direct protein tagging by PafA, the prokaryotic ubiquitin-like protein (Pup) ligase.Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis.The pupylation machinery is involved in iron homeostasis by targeting the iron storage protein ferritin.Ubiquitin-Like Proteasome System Represents a Eukaryotic-Like Pathway for Targeted Proteolysis in ArchaeaIonic strength-dependent conformations of a ubiquitin-like small archaeal modifier protein (SAMP2) from Haloferax volcanii.Prokaryotic proteasomes: nanocompartments of degradation.Proteasome activators.Pupylation-dependent and -independent proteasomal degradation in mycobacteria.AAA-ATPases in Protein Degradation.Mycobacterium tuberculosis proteasomal ATPase Mpa has a β-grasp domain that hinders docking with the proteasome core protease.Pupylation: proteasomal targeting by a protein modifier in bacteria.
P2860
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P2860
The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus
description
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im April 2010 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2010/04/07)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/04/07)
@nl
наукова стаття, опублікована у квітні 2010
@uk
مقالة علمية (نشرت في 7-4-2010)
@ar
name
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@ast
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@en
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@nl
type
label
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@ast
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@en
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@nl
prefLabel
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@ast
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@en
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@nl
P2860
P3181
P356
P1433
P1476
The mycobacterial Mpa-proteaso ...... s by engaging Pup's N-terminus
@en
P2093
Frank Striebel
Heike Summer
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.23
P407
P577
2010-03-04T00:00:00Z